Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors
A new class of potent and selective PDE5 inhibitors is disclosed. Guided by X-ray crystallographic data, optimization of an HTS lead led to the discovery of a series of 2-aryl, (N8)-alkyl substituted-6-aminosubstituted pyrido[3,2b]pyrazinones which show p
Owen, Dafydd R.,Walker, John K.,Jon Jacobsen,Freskos, John N.,Hughes, Robert O.,Brown, David L.,Bell, Andrew S.,Brown, David G.,Phillips, Christopher,Mischke, Brent V.,Molyneaux, John M.,Fobian, Yvette M.,Heasley, Steve E.,Moon, Joseph B.,Stallings, William C.,Joseph Rogier,Fox, David N.A.,Palmer, Michael J.,Ringer, Tracy,Rodriquez-Lens, Margarita,Cubbage, Jerry W.,Blevis-Bal, Radhika M.,Benson, Alan G.,Acker, Brad A.,Maddux, Todd M.,Tollefson, Michael B.,Bond, Brian R.,MacInnes, Alan,Yu, Yung
scheme or table
p. 4088 - 4091
(2010/04/02)
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