118718-59-5

Basic information

• Product Name: 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile
• Synonyms: 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile
• CAS NO: 118718-59-5
• Molecular Formula: C₁₁H₉N₃O
• Molecular Weight: 199.20866
• Mol File: 118718-59-5.mol

Chemical Properties

• Melting Point: 138-141℃ (ethanol water )
• Boiling Point: 358.1±22.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• PKA: -3.81±0.10(Predicted)
• CAS DataBase Reference: 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile(118718-59-5)
• EPA Substance Registry System: 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile(118718-59-5)

Safety Data

• Hazardous Substances Data: 118718-59-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile is used as an intermediate in the synthesis of pharmaceuticals for its potential biological and pharmacological activities. It serves as a key component in the development of drugs with analgesic and anti-inflammatory properties, contributing to the treatment of various conditions that require pain relief and inflammation control.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile is utilized as a building block in the creation of agrochemicals. Its unique structure and properties make it a valuable component in the development of pesticides, herbicides, and other agricultural chemicals that help improve crop yields and protect plants from pests and diseases.
Used in Research and Development:
1-(4-Methoxyphenyl)-1H-pyrazole-4-carbonitrile plays a significant role in research and development within the pharmaceutical and agricultural sectors. Its potential biological activities and unique chemical structure make it an important compound for exploring new drug candidates and agrochemical products. Researchers use this compound to investigate its properties and evaluate its efficacy in various applications, driving innovation and advancement in these industries.

Upstream product

• 99984-70-0 1-(4-methoxyphenyl)-1H-pyrazole-4-carbaldehyde 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 116884-64-1 (5-amino-1-(4-methoxyphenyl)-1H-pyrazole-4-carbonitrile) 
• 35715-67-4 1-(4-methoxyphenyl)-1H-pyrazole 

Downstream Products

• 1301185-12-5 1-(4-methoxyphenyl)-1H-pyrazole-4-carboximidamide 
• 1431459-44-7 5-[1-(4-methoxyphenyl)-1H-pyrazole-4-yl]-1H-tetrazole 

Relevant articles and documents

Synthesis of pyrazole-carboxamides and pyrazole-carboxylic acids derivatives: Simple methods to access powerful building blocks

Hybrid systems containing pyrazole moiety show a wide spectrum of biological activities. To access novel hybrids with pyrazole ring, in this work we synthesized twenty pyrazole-carboxylic acids and twenty pyrazole-carboxamides, using simple synthetic methods, to be used as building blocks in the development of new structures.

A Convenient Synthesis of Pyrazole-imidazoline Derivatives by Microwave Irradiation

A series of 28 hybrids pyrazole-imidazolines 1a–n and 2a–n were synthesized by a new methodology using microwave irradiation, in short time (20–30?min), in low power (50–70?W), and in 34–92% yield. Among all methodologies evaluated, no side products were obtained. All derivatives were completely characterized by FT–IR, 1H and 13C NMR, GC–MS, and HRMS.

An efficient synthesis of new 5-(1-Aryl-1H-pyrazole-4-yl)-1H-tetrazoles from 1-Aryl-1H-pyrazole-4-carbonitriles via [3 + 2] cycloaddition reaction

A series of new 5-(1-aryl-1H-pyrazole-4-yl)-1H-tetrazoles 4a-l were synthesized via [3 + 2] cycloaddition reaction from 1-aryl-1H-pyrazole-4- carbonitriles 3a-l, sodium azide and ammonium chloride, using dimethylformamide (DMF) as solvent, in good yields: 64-85%. The structures of these newly synthesized compounds were determined from the IR, 1H- and 13C-NMR spectroscopic data and elemental analyses.

Synthesis and antileishmanial activity of new 1-aryl-1H-pyrazole-4- carboximidamides derivatives

Chemotherapy for leishmaniasis, diseases caused by protozoa of the genus Leishmania, remains inefficient in several treatments. So there is a need to search for new drugs. In this work, we have synthesized 1-aryl-1H-pyrazole-4- carboximidamides derivatives and evaluated antileishmanial activities in vitro, as well as cytotoxic effects. Structure-activity relationship (SAR) studies were carried out with all the compounds of the series. Compound 2 showed an activity profile that can be improved through medicinal chemistry strategies.

New application of heterocyclic diazonium salts. Synthesis of pyrazolo[3,4-d][1,2,3]triazin-4-ones and imidazo[4,5-d][1,2,3]triazin-4-ones

The pyrazolo[3,4-d][1,2,3]triazin-4-ones 3 and imidazo[4,5-d][1,2,3] triazin-4-ones 4 are analogs structurally related to purines that have showed a wide and significant variety of biological activity. These compounds were synthesized by one-pot diazotization of 5-amino-1H-pyrazole-4-carbonitriles 1 and 5-amino-1H-imidazole-4-carbonitriles 2, respectively.