99984-70-0

Usage

Uses

Used in Pharmaceutical Industry:
1-p-methoxyphenylpyrazole-4-carboxaldehyde is used as a building block for the synthesis of various pharmaceuticals due to its inhibitory activity against certain enzymes. Its potential anti-inflammatory and analgesic properties make it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 1-p-methoxyphenylpyrazole-4-carboxaldehyde serves as a key intermediate in the synthesis of various agrochemicals, contributing to the development of effective pest control agents and other agricultural products.
Used in Organic Synthesis:
1-p-methoxyphenylpyrazole-4-carboxaldehyde is utilized as a reagent in organic synthesis, enabling the creation of a wide range of chemical compounds for various applications, including the development of new materials and the improvement of existing ones.
Used in the Preparation of Bioactive Compounds:
As a key intermediate, 1-p-methoxyphenylpyrazole-4-carboxaldehyde plays a crucial role in the preparation of various bioactive compounds, which have potential applications in medicine, agriculture, and other industries. Its unique structure and properties allow for the development of innovative and effective solutions in these fields.

Upstream product

• 497-19-8 sodium carbonate 
• 35715-67-4 1-(4-methoxyphenyl)-1H-pyrazole 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 100-97-0 hexamethylenetetramine 
• 68-12-2 N,N-dimethyl-formamide 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 118718-60-8 (1-(4-methoxyphenyl)-1H-pyrazol-4-yl)methanol 
• 118718-59-5 1-(4-methoxyphenyl)-1H-pyrazole-4-carbonitrile 
• 138907-79-6 1-(4-methoxyphenyl)-1H-pyrazole-4-carboxylic acid 
• 35715-73-2 4-(chloromethyl)-1-(4-methoxyphenyl)-1H-pyrazole 

Relevant academic research and scientific papers

Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice

The current treatments available for anxiety and depression are only palliative. Full remission has remained elusive, characterizing unmet medical needs. In the scope of an academic drug discovery program, we describe here the design, synthesis, in vitro metabolism prediction and pharmacological characterization of a new piperazine compound, 1-(4-methoxyphenyl)?4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazine (LQFM005), and of its main putative metabolite, 4-(4-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)? 1H-pyrazol-1-yl)phenol (LQFM235). The production of the metabolite was initially performed by in vitro biotransformation of LQFM005 using Aspergillus candidus and then by chemical synthesis. Oral administration of either 12 or 24 μmol/kg LQFM005 to mice did not affect spontaneous locomotor activity but increased the time spent in the center of the open field. Both LQFM005 and LQFM235 (24 μmol/kg) increased the time spent by the mice in the open arms of the elevated plus maze (EPM), a good indication of anxiolytic-like effect, and decreased the immobility time in the forced swimming test (FST), suggesting an antidepressant-like effect. The previous administration of WAY-100635 (a 5-HT1A antagonist) abolished the effects of LQFM005 in both EPM and FST. Binding experiments showed that LQFM005 and its metabolite bind to the 5-HT1A receptor with a moderate affinity (Ki around 5–9 μM). The two compounds are relatively safe, as indicated by cytotoxic assessment using the 3T3 fibroblast cell line and estimated LD50 around 600 mg/kg. In conclusion, oral administration of the newly synthesized phenylpiperazines produced anxiolytic- and antidepressant-like effects in behavioral tests, putatively in part through the activation of 5-HT1A receptors.

A pyrazolyl pyrimidine compound and use thereof

The present invention discloses a pyrazolyl pyrilamine compound, the compound has a structure as shown in formula (I), and the substituent groups in the (I) are as defined in the specification. The pyrazolyl pyrilamine compound has good control effects on downy mildew of cucumber, puccinia polysra, wheat powdery mildew and other diseases, and is especially better in the control effect on the downy mildew of cucumber.

Chemoselective and regiospecific formylation of 1-phenyl-1H-pyrazoles through the duff reaction

The synthesis of formylated 1-phenyl-1H-pyrazole derivatives under the Duff reaction conditions is reported. Our results indicate that 1-phenyl-1H-pyrazole systems containing electron-withdrawing and electron-donating substituents at the phenyl moiety rea

Synthesis and antileishmanial activity of new 1-aryl-1H-pyrazole-4- carboximidamides derivatives

Chemotherapy for leishmaniasis, diseases caused by protozoa of the genus Leishmania, remains inefficient in several treatments. So there is a need to search for new drugs. In this work, we have synthesized 1-aryl-1H-pyrazole-4- carboximidamides derivatives and evaluated antileishmanial activities in vitro, as well as cytotoxic effects. Structure-activity relationship (SAR) studies were carried out with all the compounds of the series. Compound 2 showed an activity profile that can be improved through medicinal chemistry strategies.