- Supramolecular assembly in the chiral N-carbamoyl compound 2-ureido-pentanedioic acid
-
The compound 2-ureido-pentanedioic acid was synthesized and characterized by FT-IR and NMR spectra. Its molecular structure was solved by single crystal X-ray diffraction. In the title compound, C6H10N2O5, the chiral structure is stabilized by intermolecular O-H···O and N-H···O hydrogen bonds in a supramolecular assembly formed by infinite chains parallel to the bc plane with graph set C(4) connected by amide-acid dimers R22(8) into a three-dimensional network.
- Delgado, Gerzon E.,Mora, Asiloe J.,Gonzalez, Teresa,Uzcategui, Jorge,Lobaton, Robert,Marroquin, Gustavo
-
-
Read Online
- Rapid and efficient microwave-assisted synthesis of N-carbamoyl-L-amino acids
-
A rapid and efficient method for the synthesis of N-carbamoyl-L-amino acids is reported. The procedure, involving the reaction between urea and α-amino acids sodium salts, was performed under microwave conditions using an unmodified domestic microwave oven. A careful study of the operative conditions indicated proline (1d) as the less reactive substrate and phenylglycine (1e) as the more reactive one among all the α-amino acids tested. Substitution of urea with potassium cyanate produced a low conversion into the corresponding N-carbamoyl derivative, and a possible explanation of this result is reported. Copyright Taylor & Francis Group, LLC.
- Verardo, Giancarlo,Geatti, Paola,Strazzolini, Paolo
-
-
Read Online
- PROCESS FOR THE PURIFICATION OF CARGLUMIC ACID AND INTERMEDIATE OF THIS PROCESS
-
Method of purification of carglumic acid, substance formula I, contains the following steps: a) Dissolution of carglumic acid in dimethyl sulfoxide; b) Addition of a precipitation solvent; c) Isolation of the precipitated solvate of carglumic acid with dimethyl sulfoxide; d) Release of carglumic acid from the solvate by the help of water, possibly a mixture of water and an organic solvent, possibly a mixture of water and an organic or mineral acid, possibly a mixture of water, an organic acid and a mineral acid, possibly by an activity of an organic acid, possibly by an activity of mixture of water, a mineral acid and an organic solvent.
- -
-
Page/Page column 5-6
(2021/09/08)
-
- PROCESS FOR THE SYNTHESIS OF CARGLUMIC ACID
-
The invention relates to a process for the synthesis of carglumic acid from L-glutamic acid and sodium cyanate by treatment with a lithium compound in an aqueous medium. The process according to the invention is easily industrially scalable, and is faster and cheaper than the known procedures. Formula (I)
- -
-
Page/Page column 6-7
(2020/05/19)
-
- One-pot synthesis method of N-carbamylglutamate
-
The invention discloses a one-pot synthesis method of N-carbamylglutamate, and belongs to the technical field of synthesis. The one-pot synthesis method of N-carbamylglutamate includes the steps thatwater serves as solvent, glutamic acid and cyanate serve as raw materials, alkali is added to adjust the pH value to 11-13, after a reaction is conducted for 2-4 hours at 50-90 DEG C, a mixture is cooled to room temperature and then stands for 10-15 hours, acid is added to adjust the pH value to make the mixture neutral, hydantoic acid serving as a catalyst is added, the mixture stands for 1-4 hours at 10-20 DEG C, and after filtration, recrystallization and drying are conducted, a product is obtained; the mole ratio of glutamic acid to cyanate is 1:(1.0-1.6), and the mole ratio of hydantoic acid to glutamic acid is (0.5-0.8):1. According to the one-pot synthesis method of N-carbamylglutamate, glutamic acid and cyanate serve as the raw materials, and through one-pot synthesis, N-carbamylglutamate is synthesized through the recrystallization after nucleophilic addition, the melting point obtained through tests is 152-155 DEG C, the yield is 55%, and the content is greater than 92%. Theone-pot synthesis method of N-carbamylglutamate has the advantages that the raw materials are cheap and easy to get, operation is simple, reaction conditions are mild, and the one-pot synthesis methodof N-carbamylglutamate is suitable for industrial production.
- -
-
Paragraph 0013; 0014; 0015; 0016; 0017
(2018/09/21)
-
