1188531-69-2Relevant articles and documents
Synthesis of dimeric quinazolin-2-one, 1,4-benzodiazepin-2-one, and isoalloxazine compounds as inhibitors of amyloid peptides association
Barthel, Alexander,Trieschmann, Lothar,Stroehl, Dieter,Kluge, Ralph,Boehm, Gerald,Csuk, Rene
experimental part, p. 445 - 452 (2009/12/05)
The synthesis of dimeric compounds derived from quinazolin-2-one and 1,4-benzodiazepin-2-one possessing a piperazine or homopiperazine spacer was investigated. In addition, a piperazine spacered bis-isoalloxazine and a bis-riboflavin compound were prepared and their ability to interrupt the association of prion proteins and Alzheimer-specific Aβ peptides was investigated using a fast screening system based on flow cytometry. The bis-isoalloxazine 14 was identified as a new lead structure.
