1189152-81-5

Basic information

• Product Name: (S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate
• Synonyms: (S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate
• CAS NO: 1189152-81-5
• Molecular Formula: C₁₅H₂₀BrNO₂
• Molecular Weight: 326.2288
• Mol File: 1189152-81-5.mol

Chemical Properties

• Boiling Point: 382.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.319±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -2.25±0.40(Predicted)
• CAS DataBase Reference: (S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate(1189152-81-5)
• EPA Substance Registry System: (S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate(1189152-81-5)

Safety Data

• Hazardous Substances Data: 1189152-81-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate is used as a key building block in the synthesis of various pharmaceuticals and bioactive molecules. Its unique structure and functional groups make it a versatile component in the development of new drugs and therapeutic agents.
Used in Drug Development:
In the field of drug development, (S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate is utilized for its potential therapeutic applications. Its specific stereochemistry and biological activities are being studied to explore its efficacy in treating a range of medical conditions, making it an important target for research and development.
Used in Organic Chemistry Research:
(S)-tert-butyl 2-(4-bromophenyl)pyrrolidine-1-carboxylate is also used in organic chemistry research to understand its reactivity, synthesis pathways, and potential applications in creating new chemical entities. This knowledge can contribute to the advancement of organic chemistry and the discovery of novel compounds with useful properties.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 721453-52-7 3,3'-((4-bromobenzyl)azanediyl)bis(propan-1-ol) 
• 138736-60-4 3-{[1-(4-Bromo-phenyl)-meth-(E)-ylidene]-amino}-propan-1-ol 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 1189152-85-9 (S)-2-[4-((E)-2-methoxycarbonyl-vinyl)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Enantioselective Radical Cyclization for Construction of 5-Membered Ring Structures by Metalloradical C-H Alkylation

Radical cyclization represents a powerful strategy for construction of ring structures. Traditional radical cyclization, which is based on radical addition as the key step, necessitates the use of unsaturated substrates. Guided by the concept of metalloradical catalysis, a different mode of radical cyclization that can employ saturated C-H substrates is demonstrated through the development of a Co(II)-based system for catalytic activation of aliphatic diazo compounds for enantioselective radical alkylation of various C(sp3)-H bonds. It allows for efficient construction of chiral pyrrolidines and other valuable 5-membered cyclic compounds. This alternative strategy of radical cyclization provides a new retrosynthetic paradigm to prepare five-membered cyclic molecules from readily available open-chain aldehydes through the union of C-H and C=O elements for C-C bond formation.

HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B

The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein. The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.