119169-63-0

Basic information

• Product Name: 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;Ethyl 4-chloro-1,3-diMethyl-1H-pyrazole-5-carboxylate
• CAS NO: 119169-63-0
• Molecular Formula: C8H11ClN2O2
• Molecular Weight: 202.63814
• Mol File: 119169-63-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(119169-63-0)
• EPA Substance Registry System: 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(119169-63-0)

Safety Data

• Hazardous Substances Data: 119169-63-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be incorporated into the development of new drugs, potentially leading to the discovery of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER is utilized as a precursor in the production of agrochemicals. Its role in the synthesis of these compounds contributes to the development of innovative solutions for crop protection and enhancement of agricultural productivity.
Used in Organic Synthesis:
4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER is employed as a versatile building block in organic synthesis processes. Its reactivity and structural features make it suitable for the creation of a wide range of organic compounds, expanding the scope of chemical research and applications.

Upstream product

• 4027-57-0 ethyl 5-methyl-2H-pyrazole-3-carboxylate 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 5744-40-1 ethyl 1,3-dimethylpyrazole-5-carboxylate 

Downstream Products

• 98198-65-3 1,3-dimethyl-4-chloropyrazole-5-carboxylic acid 
• 128141-47-9 1,3-dimethyl-4-chloropyrazole-5-carboxylic acid chloride 

Relevant articles and documents

Synthesis and insecticidal activities of novel 1H-pyrazole-5-carboxylic acid derivatives

Fourteen 1H-pyrazole-5-carboxylic acid derivatives containing oxazole and thiazole rings were synthesized and characterized by 1H NMR, mass spectrometry and elemental analysis. Most target compounds were obtained in overall yields in the range of 30-50%. The insecticidal activities of these new compounds against Aphis fabae were evaluated. The bioassays' results indicate that some of these compounds exhibit good activities, especially compound 7h which shows 85.7% mortality against A. fabae at a concentration of 12.5 mg/L. This activity is comparable to that of the commercial insecticide imidacloprid.

NOVEL INDAZOLE COMPOUND OR SALT THEREOF

An indazole compound represented by the following Formula (I) or a salt thereof: wherein X, R1, R2, ring A, L1, L2, L3, and R5 are as defined in this specification.

ANTICANCER COMBINATION THERAPY WITH N-(1-ACRYLOYL-AZETIDIN-3-YL)-2-((1H-INDAZOL-3-YL)AMINO)METHYL)-1H-IMIDAZOLE-5-CARBOXAMIDE INHIBITOR OF KRAS-G12C

A method of treating cancer comprises administering: (a) a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof; and (b) a therapeutically effective amount of an additional anti-cancer agent, to a subject in need of such treatment, the compound of Formula (I) being: where X, R1, R2, ring A, L1, L2, L3, and R5 are as defined in this disclosure.

PYRAZOLE DERIVATIVE

A pyrazole derivative having the following formula stru-1: The pyrazole derivative is used for prevention and control of pests.

A class of pyrazole derivatives, preparation method and application thereof (by machine translation)

The invention discloses a following formula stru - 1 indicated by the pyrazole derivatives, The definition of each substituent in the specification. This invention relates to pyrazole derivatives suitable for use in the pest. (by machine translation)

Design, Synthesis, and Acaricidal Activities of Novel Pyrazole Acrylonitrile Compounds

Using cyenopyrafen as the lead compound, a series of novel pyrazole acrylonitrile compounds were designed and synthesized via the reaction of butylphenylacetonitrile with the corresponding (substituted pyrazol-5-yl) methanone of pyrethroid alcohols in the presence of potassium tert-butoxide. These compounds showed prominent acaricidal activity against Tetranchus urticae. In particular, IIf, IIh, IIo, and IIp displayed excellent activities, which the median lethal concentrations were all lower 0.4 mg/L. In addition, the structure-activity relationship for the target compounds was discussed.

Design, synthesis and biological evaluation of 1H-pyrazole-5-carboxamide derivatives as potential fungicidal and insecticidal agents

A series of novel 1H-pyrazole-5-carboxamide compounds containing the phenyl thiazole moiety were designed and synthesized by a facile method, and their structures were characterized by 1H NMR, mass spectrometry and elemental analysis. Bioassay results showed that most of the title compounds showed potent fungicidal activities against Erysiphe graminis and insecticidal activity against Aphis fabae. Especially, compound 9b has EC50 values of 3.04 mg/L against Erysiphe graminis, of which the fungicidal activity is better than that of the commercial fungicide Thifluzamide and Azoxystrobinare; compound 9l has LC50 values of 3.81 mg/L against Aphis fabae, which was comparable with the commercial insecticide Tolfenpyrad. It is suggested that 1H-pyrazole-5-carboxamide compounds containing the phenyl thiazole moiety could be considered as a precursor structure for further design of pesticides. Graphical Abstract: A series of novel 1H-pyrazole-5-carboxamide compounds containing the phenyl thiazole moiety were designed and synthesized by a facile method, and their structures were characterized by 1H NMR, mass spectrometry and elemental analysis. Bioassay results showed that most of the title compounds showed potent fungicidal activities against Erysiphe graminis and insecticidal activity against Aphis fabae. Especially, compound 9b has EC50 values of 3.04 mg/L against Erysiphe graminis, of which the fungicidal activity is better than that of the commercial fungicide Thifluzamide and Azoxystrobinare; compound 9l has LC50 values of 3.81 mg/L against Aphis fabae, which was comparable with the commercial insecticide Tolfenpyrad. It is suggested that 1H-pyrazole-5-carboxamide compounds containing the phenyl thiazole moiety could be considered as a precursor structure for further design of pesticides.[Figure not available: see fulltext.]

PYRAZOLES AND AGRICULTURAL CHEMICALS CONTAINING THEM AS ACTIVE INGREDIENTS

A pyrazole compound represented by formula (I): wherein R1represents a hydrogen atom, a C1-4alkyl group, a C1-4haloalkyl group, a C1-4alkoxy group or a phenyl group; R2represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-4alkyl group, a C1-4alkoxy group, a C1-4haloalkoxy group, a C2-8alkoxyalkoxy group or a benzyloxy group; or R1and R2are taken together to form a group: wherein R4represents a hydrogen atom or a C1-4alkyl group; R3represents a hydrogen atom, a C1-4alkyl group, a C2-5alkenyl group, a C5-7cycloalkenyl group, a C2-5alkoxyalkyl group, a C8-12benzyloxyalkyl group, a formyl group, a C2-5alkanoyl group, a benzoyl group, a C2-5alkoxycarbonyl group, a benzyloxycarbonyl group, a C1-4alkylsulfonyl group or a C6-10arylsulfonyl group; and R represents a group represented by formulae: wherein R5represents a hydrogen atom, a halogen atom or a C1-4alkoxy group; R6represents a halogen atom, a C1-4alkyl group, a C1-4haloalkyl group, a C1-4alkoxy group or a C1-4haloalkoxy group; and n represents 1 or 2,and a pesticide, such as a fungicide, a bacteriocide, an insecticide or an acaricide, comprising the same as an active ingredient. The pyrazole compound exhibits higher pesticidal activities than conventional pesticidal compounds and are of high safety.