A novel family of 1,3,5-trisubstituted 1,2,4-triazoles was discovered as potent and selective ligands for the δ opioid receptor by rational design. Compound 5b exhibited low-nanomolar in vitro binding affinity (IC50 = 5.8 nM), excellent selecti
Peng, Youyi,Zhang, Qiang,Arora, Sonia,Keenan, Susan M.,Kortagere, Sandhya,Wannemacher, Kenneth M.,Howells, Richard D.,Welsh, William J.
experimental part
p. 6442 - 6450
(2011/02/26)
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