- Trivalent metal complex geometry of the substrate governs cathepsin B enzymatic cleavage rate
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The lysosomal protease cathepsin B recognizes defined, short peptide sequences, providing means for effective, targeted drug release. Here, we show that the introduction of a coordination complex adjacent to the cleavage sequence allows us to tune enzymatic cleavage rate by varying the complexed, trivalent metal ion.
- Ahn, Shin Hye,Boros, Eszter,Iuliano, James N.
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supporting information
p. 7289 - 7292
(2020/07/23)
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