119293-03-7

Basic information

• Product Name: Furo[3,2-b]pyridin-3(2H)-one(9CI)
• Synonyms: Furo[3,2-b]pyridin-3(2H)-one(9CI);furo[3,2-b]pyridin-3-ol;furo[3,2-b]pyridin-3(2H)-one;Furo[3,2-b]pyridin-3-one
• CAS NO: 119293-03-7
• Molecular Formula: C₇H₅NO₂
• Molecular Weight: 135.12
• Product Categories: PYRIDINE
• Mol File: 119293-03-7.mol

Chemical Properties

• Boiling Point: 289.63 °C at 760 mmHg
• Flash Point: 128.964 °C
• Appearance: /
• Density: 1.361 g/cm³
• Storage Temp.: 2-8°C
• PKA: 2.47±0.20(Predicted)
• CAS DataBase Reference: Furo[3,2-b]pyridin-3(2H)-one(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[3,2-b]pyridin-3(2H)-one(9CI)(119293-03-7)
• EPA Substance Registry System: Furo[3,2-b]pyridin-3(2H)-one(9CI)(119293-03-7)

Safety Data

• Hazardous Substances Data: 119293-03-7(Hazardous Substances Data)

Upstream product

• 119293-10-6 ethyl 3-ethoxycarbonylmethoxyfuro<3,2-b>pyridine-2-carboxylate 
• 747373-18-8 3-Ethoxy-furo[3,2-b]pyridine-2-carboxylic acid 
• 107096-00-4 furo[3,2-b]pyridin-3(2H)-one hydrochloride 
• 119293-14-0 ethyl 3-ethoxyfuro<3,2-b>pyridine-2-carboxylate 
• 119292-94-3 3-ethoxyfuro<3,2-b>pyridine 
• 107095-99-8 ethyl 3-hydroxyfuro<3,2-b>pyridine-2-carboxylate 

Relevant articles and documents

SPIROFUROPYRIDINE ARYL DERIVATIVES

Compounds of formula (I): and pharmaceutically-acceptable salts thereof, wherein: Ar is a moiety of formula (II) or (III): and A, B, and R1 are as defined in the specification, compositions containing such compounds and the use of such compounds and compositions for use in therapy.

Furopyridines. IX . Syntheses and Properties of 3-Ethoxy Derivatives of Furo-, Furo-, Furo- and Furopyridine

Reaction of ethyl 3-ethoxycarbonylmethoxyfuropyridine-2-carboxylates 2a-2d with sodium ethoxide afforded 3-ethoxy derivatives 3a-3d which converted to 3-ethoxyfuropyridines 5a-5d by hydrolysis and decarboxylation of the ester group.Vilsmeier reaction of 5a and 5b gave 2-formyl-3-ethoxy derivatives 6a and 6b and 2-formyl-3-chloro derivatives 7a and 7b, while 5c and 5d did not give any formyl compound.Bromination of 3-ethoxyfuropyridines with 1 equivalent mole of bromine gave 2-bromo-3-ethoxyfuropyridines 9a-9d, whereas reaction with 3 equivalents of bromine yielded 2,2- dibromo-3,3-diethoxy-2,3-dihydrofuropyridines (10a and 10b) and/or 2-bromo-3,3-diethoxy-2,3-dihydrofuropyridines 11b, 11c and 11d.Treatment of compounds 5a-5d with n-butyllithium in hexane-tetrahydrofuran at -70 deg C and subsequent addition of N,N-dimethylformamide yielded 2-formyl derivatives 6a-6d.