- PROCESS FOR PREPARING BICYCLO[2.2.2]OCTANE-1,4-DIOL
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Provided is a process for preparing bicyclo[2.2.2]octane-1,4-diol starting from cyclohexane-1,4-dione. The diene is reacted with certain trialkylsilyl halides or trimethylsilyl trifluormethanesulfonate in the presence of a non-nucleophilic base to afford a silyl-substituted diene, which is in turn reacted with ethylene and subsequently reduced to provide the title compound.
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Paragraph 00020
(2021/05/15)
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- SYNTHESIS OF BICYCLO[2.2.2]OCTANE DERIVATIVES
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Provided is a process for the preparation of certain 1,4-bicyclo[2.2.2]octane derivatives. The new synthetic procedure involves treating 1,4-dimethylene cyclohexane with an oxidizing agent in the presence of a transition metal catalyst to afford an oxo-substituted bicyclo[2.2.2]octane species. This intermediate structure can then be further derivatized. The processes of this disclosure thus affords a novel and simplified means for the commercial production of a wide variety of bicyclo[2.2.2]octane derivatives.
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Paragraph 0085
(2019/05/02)
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- SYNTHESIS OF BICYCLO(2.2.2)OCTANES
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Provided is a process for the preparation of certain 1,4- bicyclo[2.2.2]octane derivatives. The new synthetic procedure involves treating 1,4-dimethylene cyclohexane with an oxidizing agent in the presence of a transition metal catalyst comprising a palla
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Paragraph 0047-0048
(2018/05/15)
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- SYNTHESIS OF 1,4-DISUBSTITUTED BICYCLOOCTANES BY THE DIELS-ALDER REACTION
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Methods were developed for the synthesis of 1,4-diethoxy-, 1,4-dicyano-, and 1,4-diphenyl-1,3-cyclohexadienes.Their adducts with maleic anhydride, acrylonitrile, acrolein, nitroethylene, fumaronitrile, and α-acetoacrylonitrile were converted into the corresponding substituted bicyclooctanes.The configuration of the diene synthesis products was studied by IR and PMR spectroscopy.
- Geivandov, R.Kh.,Kovshev, E.I.
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p. 461 - 470
(2007/10/02)
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- SYNTHESIS OF BRIDGEHEAD BICYCLOOCTANOLS
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The paper describes syntheses of bicyclooctan-1-ol, its 4-methyl and 4-phenyl derivatives, and bicyclooctane-1,4-diol.
- Kopecky, Jan,Smejkal, Jaroslav,Hanus, Vladimir
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p. 1370 - 1375
(2007/10/02)
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