- S,O-Ligand-Promoted Pd-Catalyzed C?H Olefination of Anisole Derivatives
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The C?H olefination of substituted anisole derivatives by a Pd/S,O-ligand catalyst is reported. The reaction proceeds under mild conditions with a broad range of substituted aryl ethers bearing both electron donating and withdrawing substituents at ortho,
- Fernández-Ibá?ez, M. ángeles,Jia, Wen-Liang,Sukowski, Verena,van Borselen, Manuela,van Diest, Rianne
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supporting information
p. 4132 - 4135
(2021/08/24)
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- Synthesis of Bidentate Nitrogen Ligands by Rh-Catalyzed C-H Annulation and Their Application to Pd-Catalyzed Aerobic C-H Alkenylation
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A new class of bidentate ligands was prepared by a modular approach involving Rh-catalyzed C-H annulation reactions. The resulting conformationally constrained ligands enabled the Pd-catalyzed C-H alkenylation at electron-rich and sterically less hindered positions of electron-rich arenes while promoting the facile oxidation of Pd(0) intermediates by oxygen. This newly introduced ligand class is complementary to the ligands developed for Pd-catalyzed oxidative reactions and may find broad application in transition-metal-catalyzed reactions.
- Kim, Hyun Tae,Kang, Eunsu,Kim, Minkyu,Joo, Jung Min
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supporting information
p. 3657 - 3662
(2021/05/10)
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- Dual Ligand-Enabled Nondirected C?H Olefination of Arenes
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The application of the Pd-catalyzed oxidative C?H olefination of arenes, also known as the Fujiwara–Moritani reaction, has traditionally been limited by the requirement for directing groups on the substrate or the need to use the arene in large excess, ty
- Chen, Hao,Wedi, Philipp,Meyer, Tim,Tavakoli, Ghazal,van Gemmeren, Manuel
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supporting information
p. 2497 - 2501
(2018/02/06)
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- Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite
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A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution.
- Kaga, Atsushi,Hayashi, Hirohito,Hakamata, Hiroyuki,Oi, Miku,Uchiyama, Masanobu,Takita, Ryo,Chiba, Shunsuke
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p. 11807 - 11811
(2017/09/20)
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- TETRAHYDROPYRIDOTHIOPHENES AS ANTRIPOLIFERATIVE AGENTS FOR THE TREATMENT OF CANCER
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The invention relates to compounds of formula (I) wherein Ra is -C(O)ORI, in which R1 is 1-7C-a.kyl. 3-7C-cycoakyl, 1-7C-alkyl substituted by Raa, or 2-7C-alky substituted by Rab and Rac on different carbon atoms, Rb is -T-Q, in which T is 1-6C-alkylene or 3-7C-cycloalkylene, and Q is substituted by Rba and Rbb and Rbc, and is phenyl, wich are useful for the therapy of hyperprolif erative diseases, in particular human cancer.
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Page/Page column 114
(2008/06/13)
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