119595-95-8Relevant articles and documents
Synthesis of conformationally constrained lysine analogues
Ganorkar, Rakesh,Natarajan, Amarnath,Mamai, Ahmed,Madalengoitia, Jose S.
, p. 5004 - 5007 (2007/10/03)
The synthesis of two conformationally constrained lysine analogues is reported. The synthesis of the novel analogue 1 based on the 3-aza-bicyclo[3.1.0]hexane system is accomplished from the known tricycle 3 in eight steps. The synthesis of the analogue 2 is accomplished in eight steps from 4-hydroxy proline. Both analogues are synthesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis.
Synthesis of 4-Substituted Prolines as Conformationally Constrained Amino Acid Analogues
Koskinen, Ari M. P.,Rapoport, Henry
, p. 1859 - 1866 (2007/10/02)
Anionic substitution of N-(9-(9-phenylfluorenyl))-protected glutamic acid esters proceeds without loss of optical integrity to give 4-substituted glutamic acid derivatives.The 4-methyl, propyl, cyanomethyl, and phenyl analogues have thus been prepared.Pri
