Welcome to LookChem.com Sign In|Join Free
  • or


Post Buying Request

51-35-4 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
Cas No: 51-35-4
No Data No Data 10 Metric Ton/Month SICHUAN TONGSHENG AMINOACID CO.LTD Contact Supplier
Cas No: 51-35-4
No Data 500 Kilogram 500 Metric Ton/Day GUANGZHOU MEDCAN PHARMATECH LTD Contact Supplier
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
Cas No: 51-35-4
No Data 1 Metric Ton more than 10 Metric Ton/Day Chengdu Pukang Biotechnology Co., Ltd Contact Supplier
White powder L-Hydroxyproline
Cas No: 51-35-4
No Data 1 Kilogram 1500 Metric Ton/Year Siwei Development Group Ltd. Contact Supplier
Cas No: 51-35-4
No Data No Data Metric Ton/Day Cartoon Ingredients Co., Ltd Contact Supplier
Cas No: 51-35-4
No Data No Data 3 Skyrun Industrial Co.,Ltd Contact Supplier
Cas No: 51-35-4
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity trans-4-Hydroxy-L-proline with high quality and best price cas:51-35-4
Cas No: 51-35-4
USD $ 28.0-35.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality L-Hydroxyproline supplier in China
Cas No: 51-35-4
No Data 1 Kilogram 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Cas No: 51-35-4
USD $ 10.0-10.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier

51-35-4 Usage


A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys.

Chemical Properties

White crystalline powder


A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.


A versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins.


hydroxyproline is a skin-conditioning amino acid. It is a component of collagen.


ChEBI: An optically active form of 4-hydroxyproline having L-trans-configuration.

Production Methods

In the past L-Hydroxyproline was isolated by hydrolysis of animal collagen, e. g. gelatine or collagen, of which it is a major constituent. L-Hydroxyproline is an unnatural amino acid which is made in the body by hydroxylation of L-Proline. The presence of L-Hydroxyproline and proline are key to maintaining the stability of the tight collagen helix. Today L-Hydroxyproline is manufactured by bio-catalysed hydroxylation of proline in bacteria. Together with its other isomers, L-Hydroxyproline is also used as an inter mediate for a range of pharmaceutical active ingredients. Produced by hydroxylation of L-proline after protein synthesis. It is contained rich in collagen and elastin. Known to stabilization of triple-helix structure of collagen. Widely used as an intermediate for medicines.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues.

Purification Methods

Crystallise it from MeOH/EtOH (1:1). Separation from normal allo-isomer can be achieved by crystallisation of the copper salts [see Levine Biochemical Preparations 8 114 1961]. Separation from proline is achieved via the crystalline picrate, CdCl2, or acid ammonium rhodanate salts [see Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2182 1961, Kapfhammer & Mohn Z Physiol Chem 306 76 1956]. [Beilstein 22/5 V 7.]

51-35-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (H0296)  trans-4-Hydroxy-L-proline  >99.0%(HPLC)(T) 51-35-4 5g 175.00CNY Detail
TCI America (H0296)  trans-4-Hydroxy-L-proline  >99.0%(HPLC)(T) 51-35-4 25g 470.00CNY Detail
TCI America (H0296)  trans-4-Hydroxy-L-proline  >99.0%(HPLC)(T) 51-35-4 100g 1,490.00CNY Detail
Alfa Aesar (A11851)  trans-4-Hydroxy-L-proline, 99+%    51-35-4 10g 126.0CNY Detail
Alfa Aesar (A11851)  trans-4-Hydroxy-L-proline, 99+%    51-35-4 25g 266.0CNY Detail
Alfa Aesar (A11851)  trans-4-Hydroxy-L-proline, 99+%    51-35-4 100g 898.0CNY Detail
Sigma (56250)  trans-4-Hydroxy-L-proline  BioXtra, ≥99.0% (NT) 51-35-4 56250-5G 410.67CNY Detail
Sigma (56250)  trans-4-Hydroxy-L-proline  BioXtra, ≥99.0% (NT) 51-35-4 56250-25G 803.79CNY Detail
Sigma (56250)  trans-4-Hydroxy-L-proline  BioXtra, ≥99.0% (NT) 51-35-4 56250-100G 2,511.99CNY Detail
Sigma (H5534)  trans-4-Hydroxy-L-proline  BioReagent, suitable for cell culture, ≥98.5% 51-35-4 H5534-10MG 300.69CNY Detail
Sigma (H5534)  trans-4-Hydroxy-L-proline  BioReagent, suitable for cell culture, ≥98.5% 51-35-4 H5534-25G 2,417.22CNY Detail
Sigma (H5534)  trans-4-Hydroxy-L-proline  BioReagent, suitable for cell culture, ≥98.5% 51-35-4 H5534-100G 8,073.00CNY Detail
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)


What can I do for you?
Get Best Price

Get Best Price for 51-35-4