cas 1196152-38-1, 2-BroMo-5-trifluoroMethyl-pyrazine | Articles data ｜lookchem

Welcome to LookChem.com Sign In|Join Free

Article Database

Home > CAS Article list >
1196152-38-1

Articles about 1196152-38-1Total 2 be found

Article title
Article abstract
Author
Journal number and time
Download

3 -AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS
This invention relates to 3-azabicyclo[4.1.0] heptane derivatives (I) and their use as orexin receptor antagonists.
-
Page/Page column 61-62

(2010/11/05)

Selective GlyT1 inhibitors: Discovery of [4-(3-fluoro-5- trifluoromethylpyridin-2-yl)piperazin-1-yl][5-methanesulfonyl-2-((S)-2,2, 2-trifluoro-1-methylethoxy)phenyl]methanone (RG1678), a promising novel medicine to treat schizophrenia
The GlyT1 transporter has emerged as a key novel target for the treatment of schizophrenia. Herein, we report on the optimization of the 2-alkoxy-5-methylsulfonebenzoylpiperazine class of GlyT1 inhibitors to improve hERG channel selectivity and brain penetration. This effort culminated in the discovery of compound 10a (RG1678), the first potent and selective GlyT1 inhibitor to have a beneficial effect in schizophrenic patients in a phase II clinical trial.
Pinard, Emmanuel,Alanine, Alexander,Alberati, Daniela,Bender, Markus,Borroni, Edilio,Bourdeaux, Patrick,Brom, Virginie,Burner, Serge,Fischer, Holger,Hainzl, Dominik,Halm, Remy,Hauser, Nicole,Jolidon, Synese,Lengyel, Judith,Marty, Hans-Peter,Meyer, Thierry,Moreau, Jean-Luc,Mory, Roland,Narquizian, Robert,Nettekoven, Mathias,Norcross, Roger D.,Puellmann, Bernd,Schmid, Philipp,Schmitt, Sebastien,Stalder, Henri,Wermuth, Roger,Wettstein, Joseph G.,Zimmerli, Daniel
supporting information; experimental part
p. 4603 - 4614
(2010/09/17)

More Articles about upstream products of 1196152-38-1

More Articles about downstream products of 1196152-38-1

1621366-99-1
N-(3,4-difluorophenyl)-3-methyl-5-{[5-(trifluoromethyl)pyrazin-2-yl]amino}-1,2-thiazole-4-carboxamide

Chemical Properties

Boiling Point: 189.4±35.0 °C(Predicted)
Density: 1.807±0.06 g/cm3(Predicted)
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
PKA: -4.55±0.10(Predicted)
PSA: 25.78000
LogP: 2.25790

Show more

Global suppliers and manufacturers of 1196152-38-1total 17 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Zhuozhou Wenxi import and Export Co., Ltd
Business Type:Trading Company
Min Order:1 Kilogram
FOB Price:USD $ 139.0-210.0 / Kilogram
Main Products:1
Country:

Hebei Nengqian Chemical Import and Export Co., LTD
Business Type:Trading Company
Min Order:1 Kilogram
FOB Price:USD $ 9.0-99.0 / Kilogram
Main Products:165
Country:

Hangzhou J&H Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:46
Country:

Hangzhou Huarong Pharm Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:65
Country:

Suzhou Sibian Chemical Technology Co., Ltd
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:43
Country:

HANGZHOU TIANYE CHEMICALS CO., LTD.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:73
Country:

AstaTech ( Chengdu) BioPharmaceutical Corp.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:43
Country:

Shanghai Scochem Technology Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

ZHEJIANG JIUZHOU CHEM CO.,LTD
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:27
Country:

LEAP CHEM Co., Ltd.
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:88
Country:

Amadis Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:10 Milligram
FOB Price:No Data
Main Products:1
Country:

Watson International Ltd
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:1
Country:

suzhou BetterBioChem Co., Ltd.
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:1
Country:

ENAO Chemical Co, Limited
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Chemical Technology Co.,LTD
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Finetech Industry Limited
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Debye Scientific
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1196152-38-1

About us - Payment - Contact us - Links - Help Center - Disclaimer
SiteMap | Manufacturers | VIP Product | Suppliers | CAS | New CAS | Cas Database | Article Data | Chemical Catalog | Product Name

©2008 LookChem.com,License:ICP NO.:Zhejiang16009103 complaints:service@lookchem.com
[Hangzhou]86-571-87562588,87562561,87562573 Our Legal adviser: Lawyer