cas 69816-38-2, 2-Amino-5-(trifluoromethyl)pyrazine | Articles data ｜lookchem

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69816-38-2

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CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED BY TERTIARY HYDROXY GROUPS AS PI3K-GAMMA INHIBITORS
This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-y which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
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Page/Page column 157-158

(2019/05/10)

HETERCYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE
Described herein are heterocyclic compounds, compositions, and methods for their use for treatment of disease.
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Page/Page column 00223

(2018/12/13)

HETEROCYCLIC COMPOUNDS AS PI3K-y INHIBITORS
This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
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Paragraph 1377; 1378

(2018/02/28)

NOVEL MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER
2-hydroxy-benzoic anilide compounds and derivatives, compositions thereof, and methods for treating metabolic diseases and cancer through uncoupling mitochondria.
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Paragraph 0156

(2016/06/20)

QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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Page/Page column 132

(2011/05/11)

QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
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Page/Page column 82

(2009/10/31)

COMPOUNDS USEFUL FOR INHIBITING CHK1
Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in tre
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Page/Page column 49

(2008/06/13)

Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas
Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas, active as insecticides, and methods for their use as insecticides.
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(2008/06/13)

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Chemical Properties

Boiling Point: 226.204 °C at 760 mmHg
Flash Point:90.605 °C
Density: 1.461 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
PKA: 1.50±0.10(Predicted)
PSA: 51.80000
LogP: 1.65880

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