119736-83-3Relevant articles and documents
Anti-tuberculosis activity and structure–activity relationships of oxygenated tricyclic carbazole alkaloids and synthetic derivatives
B?rger, Carsten,Brütting, Christian,Julich-Gruner, Konstanze K.,Hesse, Ronny,Kumar, V. Pavan,Kutz, Sebastian K.,R?nnefahrt, Marika,Thomas, Claudia,Wan, Baojie,Franzblau, Scott G.,Kn?lker, Hans-Joachim
, p. 6167 - 6174 (2017)
A series of 49 oxygenated tricyclic carbazole derivatives has been tested for inhibition of the growth of Mycobacterium tuberculosis and a mammalian cell line (vero cells). From this series, twelve carbazoles showed a significant anti-TB activity. The four most active compounds were the naturally occurring carbazole alkaloids clauszoline-M (45), murrayaline-C (41), carbalexin-C (27), and the synthetic carbazole derivative 22 with MIC90 values ranging from 1.5 to 3.7 μM. The active compounds were virtually nontoxic for the mammalian cell line in the concentration range up to 50 μM.
Palladium(II)-catalyzed synthesis of the formylcarbazole alkaloids murrayaline A-C, 7-methoxymukonal, and 7-methoxy-o-methylmukonal
Hesse, Ronny,Krahl, Micha P.,Jaeger, Anne,Kataeva, Olga,Schmidt, Arndt W.,Knoelker, Hans-Joachim
, p. 4014 - 4028 (2014/07/08)
We describe the synthesis of the naturally occurring 2,7-dioxygenated formylcarbazole alkaloids 7-methoxymukonal, 7-methoxy-O-methylmukonal, and the murrayalines A-C. The carbazole framework was constructed by a Buchwald-Hartwig amination and a subsequent palladium(II)-catalyzed oxidative cyclization. We describe the synthesis of the naturally occurring 2,7-dioxygenated formylcarbazole alkaloids 7-methoxymukonal, 7-methoxy-O-methylmukonal, and the murrayalines A-C. The carbazole framework was constructed by a Buchwald-Hartwig amination and a subsequent palladium(II)-catalyzed oxidative cyclization. Copyright
