1114808-93-3Relevant articles and documents
Diastereoselective Intramolecular Heck Reaction Assisted by an Acetate Group: Synthesis of the Decahydrobenzofluorene Derivative Dasyscyphin e
Jiménez, Fermín,Fernández, Antonio,Boulifa, Ettahir,Mansour, Ahmed Ibn,Alvarez-Manzaneda, Ramón,Chahboun, Rachid,Alvarez-Manzaneda, Enrique
, p. 9550 - 9559 (2017)
The first synthesis of antifungal sesquiterpene quinol dasyscyphin E was achieved starting from trans-communic acid. The process described involves the first diastereoselective synthesis of this type of compound by cyclization of an aryl bicyclosesquiterpene. The acid was efficiently transformed into a sesquiterpene synthon, which was converted into the corresponding bromoaryl sesquiterpene. The key step of synthetic sequence was the cyclization of the latter under Heck reaction conditions, which yielded the tetracyclic skeleton of the target compound with complete diastereoselectivity. The participation of an acetate group is decisive, both for the course of the Heck reaction and for the stereoselectivity of the process.
2,5-DIALKYL-4-H/HALO/ETHER-PHENOL COMPOUNDS
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Paragraph 0190, (2015/06/03)
The present disclosure provides phenolic compounds useful in the treatment of neurological conditions such as convulsions and tremors, having the structure of Formula (I): wherein R2, R4, and R5, are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating neurological conditions.
FLASH AND GLOW 1,2-DIOXETANES
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Page/Page column 101, (2012/11/14)
Compounds having chemiluminescent flash and glow properties. Also disclosed are methods using the compounds to generate light, detect and/or quantify enzymes, antigens, and/or nucleic acids. Also disclosed are kits relating to these compounds.