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Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo-, phenylmethyl ester, (2S)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 119768-48-8 Structure
  • Basic information

    1. Product Name: Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo-, phenylmethyl ester, (2S)-
    2. Synonyms:
    3. CAS NO:119768-48-8
    4. Molecular Formula: C16H22INO4
    5. Molecular Weight: 419.259
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 119768-48-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo-, phenylmethyl ester, (2S)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo-, phenylmethyl ester, (2S)-(119768-48-8)
    11. EPA Substance Registry System: Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo-, phenylmethyl ester, (2S)-(119768-48-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 119768-48-8(Hazardous Substances Data)

119768-48-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 119768-48-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,9,7,6 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 119768-48:
(8*1)+(7*1)+(6*9)+(5*7)+(4*6)+(3*8)+(2*4)+(1*8)=168
168 % 10 = 8
So 119768-48-8 is a valid CAS Registry Number.

119768-48-8Relevant articles and documents

o-Boronato- and o-Trifluoroborato - Phosphonium Salts Supported by L-α-Amino Acid Side Chain

Bernard, Julie,Malacea-Kabbara, Raluca,Clemente, Gon?alo S.,Burke, Benjamin P.,Eymin, Marie-Jo?lle,Archibald, Stephen J.,Jugé, Sylvain

, p. 4289 - 4298 (2015)

(Figure Presented) The synthesis of o-boronato- and o-trifluoroborato-phosphonium salts supported by the l-amino acid side chain is described. The synthesis of these new class of amino acid derivatives was achieved by stereoselective quaternization of o-(

Method for synthesizing L- cystathionine hydrochloride (by machine translation)

-

Paragraph 0007; 0020; 0025-0026, (2020/07/24)

The invention relates to a synthetic method of L - cystathionine hydrochloride. The method mainly solves the technical problems of potential safety hazards and difficulty in purification in the existing synthetic method. To L - homoserine which can be lar

VERSATILE AND STEREOSPECIFIC SYNTHESIS OF GAMMA,DELTA -UNSATURATED AMINO ACIDS BY WITTIG REACTION

-

Page/Page column 39; 40, (2013/03/28)

The present invention relates to γ,δ-unsaturated a-amino acids of general formula (I). The present invention also provides a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. The present invention also relates to intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I).

Efficient synthesis of benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-ω- iodoalkanoates

Koseki, Yohei,Yamada, Haruka,Usuki, Toyonobu

, p. 580 - 586 (2011/06/21)

The efficient synthesis of four benzyl 2-(S)-[(tert-butoxycarbonyl)amino]- ω-iodoalkanoates {benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-3- iodopropanoate, benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-4-iodobutanoate, benzyl 2-(S)-[(tert-butoxycarbonyl)amino]-

NOVEL GAMMA-LACTAMS AS BETA-SECRETASE INHIBITORS

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Page 43; 113, (2008/06/13)

There is provided a series of novel substituted gamma-lactams of Formula (I) wherein R1, R2, R3, R4 and R5 are defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of aβ-peptide. The present invention is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

SUBSTITUTED QUINOLINE CCR5 RECEPTOR ANTAGONISTS

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Page 147-149, (2010/02/06)

The present invention relates to CCR5 receptor antagonists of formulae (1a) or (1b), enantiomers, diastereomers, salts and solvates thereof wherein R1, R2, R3, R4, R5, and R7 are as defined herein. The invention further includes a method of CCR5-mediated

Concise Synthesis of Enantiomerically Pure Phenylalanine, Homophenylalanine, and Bishomophenylalanine Derivatives Using Organozinc Chemistry: NMR Studies of Amino Acid-Derived Organozinc Reagents

Jackson, Richard F. W.,Moore, Rebecca J.,Dexter, Charles S.,Elliott, Jason,Mowbray, Charles E.

, p. 7875 - 7884 (2007/10/03)

Protected phenylalanines 23 (seven examples), homophenylalanines 7 (eight examples), and bishomophenylalanines 8 (seven examples) have been prepared by palladium-catalyzed coupling of the amino acid-derived organozinc reagents 13, 5, and 6, respectively, with aryl iodides. While the reactions of the zinc reagent 13 may be conducted in both THF and DMF as solvent, the results obtained in DMF are generally superior. In the case of the reagents 5 and 6 the results are far superior in DMF. NMR investigations on the structure of the zinc reagents 13 in THF suggest that there is strong intramolecular coordination of the urethane carbonyl group, whereas in DMF this interaction is completely suppressed.

Synthesis of α-amino acids using amino acid γ-anion equivalents: Synthesis of 5-oxo α-amino acids, homophenylalanine derivatives and pentenylglycines

Jackson, Richard F. W.,Fraser, Joanne L.,Wishart, Neil,Porter, Barry,Wythes, Martin J.

, p. 1903 - 1912 (2007/10/03)

Treatment of protected iodohomoalanine 7 with Rieke copper leads to the formation of an organocopper reagent 10 which reacts with electrophiles in moderate yield to give enantiomerically pure α-amino acid derivatives 11, 12 and 13. Alternatively, reaction of the fully protected iodohomoalanine derivative 15 with activated zinc gives the corresponding alkylzinc iodide 14, which reacts under palladium catalysis with a range of electrophiles (aryl iodides and acid chlorides) to give the corresponding adducts 19 and 22. While the reactions with aryl iodides provide acceptable yields in THF as solvent, the corresponding reactions with acid chlorides requires dimethoxyethane or, preferably, a combination of toluene and dimethylacetamide under ultrasonication, for good results. The alkylzinc iodide 14 can be transformed into a zinc-copper reagent 16 which reacts with allylic halides, and with reactive acid chlorides, to give the corresponding adducts 221, 24-26 in reasonable yields.

MANIPULATION OF THE CARBOXYL GROUPS OF α-AMINO-ACIDS AND PEPTIDES USING RADICAL CHEMISTRY BASED ON ESTERS OF N-HYDROXY-2-THIOPYRIDONE

Barton, Derek H. R.,Herve, Yolande,Potier, Pierre,Thierry, Josiane

, p. 5479 - 5486 (2007/10/02)

Photolysis of α-amino-acid or peptide esters derived from N-hydroxy-2-thiopyridone in the presence of t-butylthiol affords the expected decarboxylation products in good yield.The reaction can be applied to the α-carboxyl or to the side chain carboxyl of g

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