Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo-, phenylmethyl ester, (2S)-

Base Information

Chemical Name:Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo-, phenylmethyl ester, (2S)-
CAS No.:119768-48-8
Molecular Formula:C16H22INO4
Molecular Weight:419.259
Hs Code.:
Mol file:119768-48-8.mol

Synonyms:

Suppliers and Price of Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo-, phenylmethyl ester, (2S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo-, phenylmethyl ester, (2S)-

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo-, phenylmethyl ester, (2S)-

There total 17 articles about Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-4-iodo-, phenylmethyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1426140-83-1
benzyl (S)-4-iodo-2-[N,N-bis(tert-butyloxycarbonyl)amino]butanoate

: 119768-48-8
(S)-2-((tert-butoxycarbonyl)amino)-4-iodobutyric acid benzyl ester

Guidance literature:: With cerium(III) chloride heptahydrate; sodium iodide; In acetonitrile; at 20 ℃;

Reference yield: 82.0%

: 105183-60-6
(S)-benzyl 2-((tert-butoxycarbonyl)amino)-4-hydroxybutanoate

: 119768-48-8
(S)-2-((tert-butoxycarbonyl)amino)-4-iodobutyric acid benzyl ester

Guidance literature:: (S)-benzyl 2-((tert-butoxycarbonyl)amino)-4-hydroxybutanoate; With methanesulfonyl chloride; triethylamine; In acetonitrile; at 0 - 20 ℃; for 6h;

With sodium iodide; In N,N-dimethyl-formamide; at 70 ℃; for 4h; Reagent/catalyst;

Reference yield:

: 30925-18-9
2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester

: 119768-48-8
(S)-2-((tert-butoxycarbonyl)amino)-4-iodobutyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1,3-dicyclohexylcarbodiimide / ethyl acetate / 6 h / Ambient temperature

2: NaBH₄ / tetrahydrofuran; H₂O

3: 68 percent / Ph₃P, imidazole, I₂ / CH₂Cl₂ / 1 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; iodine; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo981133u