119825-08-0

Basic information

• Product Name: 2-Amino-4-phenyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile
• Synonyms: 2-Amino-4-phenyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile
• CAS NO: 119825-08-0
• Molecular Formula: C₁₉H₁₃N₃O
• Molecular Weight: 299.33
• Mol File: 119825-08-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Amino-4-phenyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-phenyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile(119825-08-0)
• EPA Substance Registry System: 2-Amino-4-phenyl-4H-pyrano[3,2-h]quinoline-3-carbonitrile(119825-08-0)

Safety Data

• Hazardous Substances Data: 119825-08-0(Hazardous Substances Data)

Upstream product

• 148-24-3 8-quinolinol 
• 100-52-7 benzaldehyde 
• 109-77-3 malononitrile 
• 2700-22-3 Benzylidenemalononitrile 

Downstream Products

• 133620-68-5 2-(hydrazinomethyleneamino)-4-phenyl-4H-pyrano<3,2-h>quinoline-3-carbonitrile 
• 133620-72-1 2-(methylaminomethyleneamino)-4-phenyl-4H-pyrano<3,2-h>quinoline-3-carbonitrile 
• 133620-67-4 2-(ethoxymethyleneamino)-4-phenyl-4H-pyrano<3,2-h>quinoline-3-carbonitrile 
• 133620-63-0 8-amino-7-phenyl-7H-pyrimido<4',5':6,5>pyrano<3,2-h>quinoline 
• 133620-61-8 2-acetamino-4-phenyl-4H-pyrano<3,2-h>quinoline-3-carbonitrile 
• 133620-62-9 10-methyl-7-phenyl-7H-pyrimido<4',5':6,5>pyrano<3,2-h>quinolin-8(9H)-one 
• 133620-64-1 7-phenyl-7H-pyrimido<4',5':6,5>pyrano<3,2-h>quinolin-8(9H)-one 
• 133620-65-2 7-phenyl-7H-pyrimido<4',5':6,5>pyrano<3,2-h>quinolin-8,10-dithiol 

Relevant articles and documents

Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy

Herein we report an efficient two step synthesis and biological assessment of 12 racemic tetrahydropyranodiquinolin-8-amines derivatives as antioxidant, cholinesterase inhibitors and non-hepatotoxic agents. Based on the results of the primary screening, we identified 7-(3-methoxyphenyl)-9,10,11,12-tetrahydro-7H-pyrano[2,3-b:5,6-h']diquinolin-8-amine (2h) as a particularly interesting non-hepatotoxic compound that shows moderate antioxidant activity (1.83 equiv Trolox in the ORAC assay), a non competitive inhibition of hAChE (IC50= 0.75 ± 0.01 μM), and brain permeable as determined by the PAMPA-Blood Brain Barrier assay.

InCl3 promoted synthesis of pyrano[3,2-h]quinolines via microwave irradiation

An efficient and economical method has been developed for the synthesis of pyrano[3,2-h]quinolines via an indium trichloride-catalyzed one-pot three-component reaction of 8-hydroxyquinoline with aromatic aldehydes and malononitrile/ethyl cyanoacetate unde

Ce-Zr/SiO2: A versatile reusable heterogeneous catalyst for three-component synthesis and solvent free oxidation of benzyl alcohol

Ce-Zr loaded on SiO2 as catalyst provides an extremely efficient method to synthesize pyranoquinolines. This catalyst is found to be superb for the three-component synthesis of target compounds and for the solvent-free liquid-phase oxidation of benzyl alcohols. The catalyst is fully recoverable and reusable with no loss of catalytic activity even after multiple cycles.

Microwave assisted synthesis of 2-amino-4-(aryl)-4H-pyrano [3,2-H] quinoline-3-carbonitriles in polyethylene glycol and their antibacterial activity

A series of 2-amino-4-(aryl)-4H-pyrano [3,2-h] quinoline-3-carbonitriles have been synthesized by microwave assisted multicomponent one-pot cyclocondensation reaction of aromatic aldehydes, malononitrile and 8-hydroxy quinoline in PEG-400. All these compo

NITRILES IN HETEROCYCLIC SYNTHESIS: NOVEL SYNTHESES OF BENZOPYRANS, NAPHTHOPYRANS, NAPHTHOPYRANS, PYRANOQUINOLINES AND PYRANOQUINOLINES

Benzopyrans, naphthopyrans, naphthopyrans, pyranoquinolines, and pyranoquinolines were synthesized by the reaction of cinnamonitriles with phenols, naphthols, 8-hydroxyquinoline, and 1-methyl-4-hydroxy-2-quinolone.