- COMPOUNDS MODULATING PROTEIN RECRUITMENT AND/OR DEGRADATION
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The invention provides cereblon binders for the degradation of proteins by the ubiquitin proteasome pathway for therapeutic applications.
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Paragraph 0667; 0670
(2021/06/26)
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- SPIROCYCLIC COMPOUNDS
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The present invention provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.
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Page/Page column 187
(2019/11/12)
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- New Phosphonium Ylides by Functionalization of Triphenylphosphoranylideneacetamide
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Triphenylphosphoranylideneacetamide undergoes Michael reactions with several acceptors, giving rise, apart from the normal Michael adducts, to the formation of different products like glutarimide ylides and stabilized iminophosphoranes.Wittig reactions with these new ylides lead to a variety of α,β-unsaturated carbonyl compounds. Key Words: Stabilized phosphonium ylides, Wittig reaction, Michael reaction, Glutarimides.
- Wanner, Martin J.,Koomen, Gerrit-Jan
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p. 1513 - 1516
(2007/10/02)
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- Biomimetic Synthesis of Quinolizidine Alkaloids
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Quinolizidine alkaloids are synthesized from glutarimide ylides via a piperidine ring transformation that is based on the lupinine biosynthesis.A short enantioselective bispiperidine synthesis using R-phenylglycinol as a chiral precursor is described.Key
- Wanner, Martin J.,Koomen, Gerrit-Jan
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p. 8431 - 8442
(2007/10/02)
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- SYNTHESIS OF (+/-)-NITRAMINE, (+/-)-ISONITRAMINE AND (+/-)-SIBIRINE VIA DIELS-ALDER REACTIONS
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Diels-Alder reactions with N-protected methyleneglutarimides are used to construct the spiro-framework during the synthesis of the title alkaloids.
- Wanner, M.J.,Koomen, G.J.
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p. 2301 - 2304
(2007/10/02)
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- 2-Substituted Glutarimides via Preformed Wittig Reagents
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Triphenylphosphoranylideneacetamide (1) reacts with some Michael-acceptors to give crystalline 2-triphenylphosphoranylidene glutarimides.The Wittig reaction of 2 with several aldehydes in refluxing 1,2-dichloroethane affords the corresponding 2-alkylidene
- Wanner, M. J.,Koomen, G. J.
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p. 325 - 327
(2007/10/02)
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