119930-84-6

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 38821-11-3 2-(triphenylphosphoranylidene)acetamide 
• 25361-54-0 (2-amino-2-oxo-ethyl)triphenyl-phosphonium chloride 
• 603-35-0 triphenylphosphine 
• 140-88-5 ethyl acrylate 

Downstream Products

• 123435-88-1 (6R,7S)-2-Benzyl-7-trimethylsilanyloxy-2-aza-spiro[5.5]undec-8-ene-1,3-dione 
• 123435-88-1 (6R,7R)-2-Benzyl-7-trimethylsilanyloxy-2-aza-spiro[5.5]undec-8-ene-1,3-dione 
• 49620-06-6 (+/-)-isonitramine 
• 123435-90-5 1-benzyl-3-methylidenepiperidine-2,6-dione 
• 142643-42-3 (6S,7R,11R)-2-Benzyl-7-(1-benzyl-2,6-dioxo-piperidin-3-yl)-11-phenylsulfanyl-2-aza-spiro[5.5]undecane-1,3-dione 
• 141263-70-9 3-[2,6-Dioxo-5-(triphenyl-λ⁵-phosphanylidene)-piperidin-3-yl]-propionamide 
• 141263-73-2 C₂₆H₂₅N₂O₃P 
• 141263-81-2 3-{2,6-Dioxo-5-[1-phenyl-meth-(E)-ylidene]-piperidin-3-yl}-propionamide 
• 119930-89-1 3-[1-Phenyl-meth-(E)-ylidene]-piperidine-2,6-dione 
• 119930-89-1 (E)-3-benzylidenepiperidine-2,6-dione 
• 119930-91-5 3-[1-[(4R,5S)-5-((S)-1-Hydroxy-2-trityloxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-meth-(Z)-ylidene]-piperidine-2,6-dione 
• 119930-91-5 3-[1-[(4R,5S)-5-((S)-1-Hydroxy-2-trityloxy-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-meth-(E)-ylidene]-piperidine-2,6-dione 
• 119930-92-6 3-[1-((4R,4aS,8aS)-2,6-Diphenyl-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl)-meth-(Z)-ylidene]-piperidine-2,6-dione 
• 119930-92-6 3-[1-((4R,4aS,8aS)-2,6-Diphenyl-tetrahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl)-meth-(E)-ylidene]-piperidine-2,6-dione 

Relevant academic research and scientific papers

COMPOUNDS MODULATING PROTEIN RECRUITMENT AND/OR DEGRADATION

The invention provides cereblon binders for the degradation of proteins by the ubiquitin proteasome pathway for therapeutic applications.

SPIROCYCLIC COMPOUNDS

The present invention provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.

New Phosphonium Ylides by Functionalization of Triphenylphosphoranylideneacetamide

Triphenylphosphoranylideneacetamide undergoes Michael reactions with several acceptors, giving rise, apart from the normal Michael adducts, to the formation of different products like glutarimide ylides and stabilized iminophosphoranes.Wittig reactions with these new ylides lead to a variety of α,β-unsaturated carbonyl compounds. Key Words: Stabilized phosphonium ylides, Wittig reaction, Michael reaction, Glutarimides.

Biomimetic Synthesis of Quinolizidine Alkaloids

Quinolizidine alkaloids are synthesized from glutarimide ylides via a piperidine ring transformation that is based on the lupinine biosynthesis.A short enantioselective bispiperidine synthesis using R-phenylglycinol as a chiral precursor is described.Key

SYNTHESIS OF (+/-)-NITRAMINE, (+/-)-ISONITRAMINE AND (+/-)-SIBIRINE VIA DIELS-ALDER REACTIONS

Diels-Alder reactions with N-protected methyleneglutarimides are used to construct the spiro-framework during the synthesis of the title alkaloids.

2-Substituted Glutarimides via Preformed Wittig Reagents

Triphenylphosphoranylideneacetamide (1) reacts with some Michael-acceptors to give crystalline 2-triphenylphosphoranylidene glutarimides.The Wittig reaction of 2 with several aldehydes in refluxing 1,2-dichloroethane affords the corresponding 2-alkylidene