cas 120008-53-9, N-(8-amino-1-carboxyoctyl)-alanyl-proline | Articles data ｜lookchem

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120008-53-9

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Synthesis and angiotensin converting enzyme inhibitory activity of N-carboxymethyldipeptides with an ω-aminoalkyl group
A series of novel L-alanyl- and L-lysyl-L-proline derivatives having an ω-amino-1-carboxyalkyl group was prepared, and assayed for their inhibitory activity against angiotensin converting enzyme (ACE). The dicarboxylic acids possessing S,S,S configuration showed potent in vitro ACE inhibitory activity with IC50 values of 0.68-1.4 nmol/l. The length of the carbon chain in the ω-aminoalkyl moiety was varied from 6 to 9 investigate the optimal structure for long-acting ACE inhibitors. The most prolonged activity in vivo was observed with N-[8-amino-1(s)-carboxyoctyl]-L-alanyl-L-proline upon i.v. and p.o.
Saito,Matsui,Watanabe,Waga,Kajiwara,Shirota,Iijima,Kitabatake
p. 257 - 260
(2007/10/02)

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Chemical Properties

Boiling Point: 596.5°Cat760mmHg
Flash Point:314.5°C
Density: 1.206g/cm³
Vapor Pressure: 9.06E-16mmHg at 25°C
PSA: 132.96000
LogP: 1.82170

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