1201676-03-0

Basic information

• Product Name: 1H-Pyrrolo[3,4-c]pyridin-1-one, 4,6-dichloro-2,3-dihydro-
• Synonyms: 1H-Pyrrolo[3,4-c]pyridin-1-one, 4,6-dichloro-2,3-dihydro-;4,6-DICHLORO-2,3-DIHYDROPYRROLO[3,4-C]PYRIDIN-1-ONE;4,6-Dichloro-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-one
• CAS NO: 1201676-03-0
• Molecular Formula: C7H4Cl2N2O
• Molecular Weight: 203.02546
• Mol File: 1201676-03-0.mol

Chemical Properties

• Boiling Point: 525.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.583±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.65±0.20(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[3,4-c]pyridin-1-one, 4,6-dichloro-2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[3,4-c]pyridin-1-one, 4,6-dichloro-2,3-dihydro-(1201676-03-0)
• EPA Substance Registry System: 1H-Pyrrolo[3,4-c]pyridin-1-one, 4,6-dichloro-2,3-dihydro-(1201676-03-0)

Safety Data

• Hazardous Substances Data: 1201676-03-0(Hazardous Substances Data)

Usage

Compound type

Heterocyclic organic compound

Structure

Contains a pyrrolopyridine ring system with chlorine substitutions

Potential applications

Pharmaceutical and agrochemical industries, development of new drugs, precursor in organic synthesis

Safety measures

Proper handling and safety measures should be taken into consideration when working with this compound to ensure the safety of workers and the environment.

Upstream product

• 1201676-02-9 3-bromomethyl-2,6-dichloroisonicotinic acid ethyl ester 
• 137520-99-1 2,6-dichloro-3-methylisonicotinic acid ethyl ester 

Downstream Products

• 1201676-04-1 4-(6-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 1201676-05-2 4-(4-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)piperazine-1-carboxylic acid tert-butyl ester 
• 1201674-76-1 4-(2-cyclohexylaminopyridin-4-yl)-6-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one 
• 1201674-74-9 6-(2-cyclohexylaminopyridin-4-yl)-4-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one 
• 1201674-77-2 6-(2-cyclohexylamino-pyridin-4yl)-4-(5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-2,3-dihydro-pyrrolo[3,4-c]pyridin-1-one 
• 1201676-06-3 4-[6-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl]piperazine-1-carboxylic acid tert-butyl ester 
• 1201676-07-4 4-[4-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl]piperazine-1-carboxylicacid tert-butyl ester 
• 1201674-78-3 1-[6-(2-cyclohexylamino-pyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl]-piperidine-4-carboxylic acid isobutyl-amide 

Relevant articles and documents

Identification of potent and selective amidobipyridyl inhibitors of protein kinase D

The synthesis and biological evaluation of potent and selective PKD inhibitors are described herein. The compounds described in the present study selectively inhibit PKD among other putative HDAC kinases. The PKD inhibitors of the present study blunt phosphorylation and subsequent nuclear export of HDAC4/5 in response to diverse agonists. These compounds further establish the central role of PKD as an HDAC4/5 kinase and enhance the current understanding of cardiac myocyte signal transduction. The in vivo efficacy of a representative example compound on heart morphology is reported herein.

2,4'-BIPYRIDINYL COMPOUNDS AS PROTEIN KINASE D INHIBITORS USEFUL FOR THE TREATMENT OF IA HEART FAILURE AND CANCER

The present invention provides novel organic compounds of Formula I: methods of use, and pharmaceutical compositions thereof.