1201676-05-2

Basic information

• Product Name: 1-Piperazinecarboxylic acid, 4-(4-chloro-2,3-dihydro-1-oxo-1H-pyrrolo[3,4-c]pyridin-6-yl)-, 1,1-diMethylethyl ester
• Synonyms: 1-Piperazinecarboxylic acid, 4-(4-chloro-2,3-dihydro-1-oxo-1H-pyrrolo[3,4-c]pyridin-6-yl)-, 1,1-diMethylethyl ester;4-(4-chloro-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 1201676-05-2
• Molecular Formula: C₁₆H₂₁ClN₄O₃
• Molecular Weight: 352.81594
• Mol File: 1201676-05-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Piperazinecarboxylic acid, 4-(4-chloro-2,3-dihydro-1-oxo-1H-pyrrolo[3,4-c]pyridin-6-yl)-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, 4-(4-chloro-2,3-dihydro-1-oxo-1H-pyrrolo[3,4-c]pyridin-6-yl)-, 1,1-diMethylethyl ester(1201676-05-2)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, 4-(4-chloro-2,3-dihydro-1-oxo-1H-pyrrolo[3,4-c]pyridin-6-yl)-, 1,1-diMethylethyl ester(1201676-05-2)

Safety Data

• Hazardous Substances Data: 1201676-05-2(Hazardous Substances Data)

Usage

Molecular weight

454.96 g/mol

Structure

A t-butyl ester derivative of piperazinecarboxylic acid with a pyrrolopyridine ring system

Properties

+ Potential antiviral, antifungal, and anticancer properties
+ Shows promise in the treatment of various diseases
+ An important target for further investigation in the field of medicinal chemistry and drug development

Uses

Pharmaceutical intermediate for the synthesis of various drugs

Upstream product

• 137520-99-1 2,6-dichloro-3-methylisonicotinic acid ethyl ester 
• 1201676-02-9 3-bromomethyl-2,6-dichloroisonicotinic acid ethyl ester 
• 1201676-03-0 4,6-dichloro-2,3-dihydropyrrolo[3,4-c]pyridin-1-one 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 1201676-07-4 4-[4-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl]piperazine-1-carboxylicacid tert-butyl ester 
• 1201674-76-1 4-(2-cyclohexylaminopyridin-4-yl)-6-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one 

Relevant articles and documents

Identification of potent and selective amidobipyridyl inhibitors of protein kinase D

The synthesis and biological evaluation of potent and selective PKD inhibitors are described herein. The compounds described in the present study selectively inhibit PKD among other putative HDAC kinases. The PKD inhibitors of the present study blunt phosphorylation and subsequent nuclear export of HDAC4/5 in response to diverse agonists. These compounds further establish the central role of PKD as an HDAC4/5 kinase and enhance the current understanding of cardiac myocyte signal transduction. The in vivo efficacy of a representative example compound on heart morphology is reported herein.