1202-81-9

Basic information

• Product Name: 4-phenyltetrahydro-2H-pyran-4-carbonitrile
• Synonyms: 4-phenyltetrahydro-2H-pyran-4-carbonitrile;2H-pyran-4-carbonitrile, tetrahydro-4-phenyl-;4-phenyl-4-tetrahydropyrancarbonitrile;4-phenyloxane-4-carbonitrile;4-phenyltetrahydropyran-4-carbonitrile
• CAS NO: 1202-81-9
• Molecular Formula: C₁₂H₁₃NO
• Molecular Weight: 187.23772
• Mol File: 1202-81-9.mol

Chemical Properties

• Melting Point: 49-50 °C
• Boiling Point: 339.6°C at 760 mmHg
• Flash Point: 143.3°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 9.09E-05mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: 4-phenyltetrahydro-2H-pyran-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyltetrahydro-2H-pyran-4-carbonitrile(1202-81-9)
• EPA Substance Registry System: 4-phenyltetrahydro-2H-pyran-4-carbonitrile(1202-81-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1202-81-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-phenyltetrahydro-2H-pyran-4-carbonitrile serves as a key intermediate in organic synthesis, where its reactive functional groups facilitate the creation of a wide range of chemical products. Its versatility in participating in numerous chemical reactions makes it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research and Development:
In the pharmaceutical industry, 4-phenyltetrahydro-2H-pyran-4-carbonitrile is utilized as a crucial building block for the development of new pharmaceuticals. Its potential biological activity and the ability to form various derivatives make it a promising candidate for the creation of novel drugs with potential therapeutic properties.
Used in Agrochemical Production:
4-phenyltetrahydro-2H-pyran-4-carbonitrile also finds application in the agrochemical sector, where it is employed as an intermediate in the synthesis of various agrochemicals. Its role in this industry is instrumental in developing products that can enhance crop protection and yield.
Used in the Development of Therapeutic Agents:
Given its potential biological activity, 4-phenyltetrahydro-2H-pyran-4-carbonitrile is being investigated for its possible use in the treatment of various diseases. Its exploration as a therapeutic agent underscores the compound's capacity to contribute to advancements in medical treatments.

InChI:InChI=1/C12H13NO/c13-10-12(6-8-14-9-7-12)11-4-2-1-3-5-11/h1-5H,6-9H2

Upstream product

• 140-29-4 phenylacetonitrile 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 14006-32-7 C-(4-phenyl-tetrahydro-pyran-4-yl)-methylamine 

Downstream Products

• 855628-79-4 1-(4-phenyl-tetrahydropyran-4-yl)-ethanone 
• 182491-21-0 4-phenyltetrahydro-2H-pyran-4-carboxylic acid 
• 109188-31-0 5-(4-phenyl-tetrahydro-pyran-4-yl)-1⁽²⁾H-tetrazole 
• 723272-14-8 4-bromo-2-(2-bromo-ethyl)-2-phenyl-butyric acid 
• 100119-45-7 4-phenyltetrahydropyran-4-carbonyl chloride 
• 88782-31-4 4-phenyl-tetrahydro-pyran-4-carboxylic acid-(2-diethylamino-ethyl ester); hydrochloride 
• 20638-52-2 4-phenyltetrahydro-2H-pyran 

Relevant articles and documents

Hydride Reduction by a Sodium Hydride-Iodide Composite

Sodium hydride (NaH) is widely used as a Br?nsted base in chemical synthesis and reacts with various Br?nsted acids, whereas it rarely behaves as a reducing reagent through delivery of the hydride to polar π electrophiles. This study presents a series of reduction reactions of nitriles, amides, and imines as enabled by NaH in the presence of LiI or NaI. This remarkably simple protocol endows NaH with unprecedented and unique hydride-donor chemical reactivity.

Synthesis of nitriles from amines using nanoscale Co3O4-based catalysts via sustainable aerobic oxidation

The selective oxidation of amines for the benign synthesis of nitriles under mild conditions is described. Key to success for this transformation is the application of reusable cobalt oxide-based nanocatalysts. The resulting nitriles constitute key precursors and central intermediates in organic synthesis.

"Nanorust"-catalyzed benign oxidation of amines for selective synthesis of nitriles

Organic nitriles constitute key precursors and central intermediates in organic synthesis. In addition, nitriles represent a versatile motif found in numerous medicinally and biologically important compounds. Generally, these nitriles are synthesized by traditional cyanation procedures using toxic cyanides. Herein, we report the selective and environmentally benign oxidative conversion of primary amines for the synthesis of structurally diverse aromatic, aliphatic and heterocyclic nitriles using a reusable "nanorust" (nanoscale Fe2O3)-based catalysts applying molecular oxygen.

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (I) wherein G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, u, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.