- Ecofriendly synthesis of tetrahydropyrimidine derivatives in aqueous medium under ultrasonic irradiation
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A simple, efficient, and ecofriendly procedure was developed for the synthesis of 2-substituted 1,4,5,6-tetrahydropyrimidine derivatives catalyzed by N-bromosuccinimide using ultrasonic irradiation in aqueous medium. Prominent advantages of this new method are good yields, aqueous medium, short reaction times, and easy workup procedure. The compounds were characterized by infrared, NMR, liquid chromatography-mass spectrometry, and elemental analyses.
- Koteswara Rao, Valasani,Hari Babu, Boppudi,Raveendra Babu, Kilaru,Srinivasulu, Doddaga,Naga Raju, Chamarthi
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experimental part
p. 3368 - 3376
(2012/09/08)
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- Efficient synthesis of pyrimido[1,2-c] [1,3]benzothiazin-6-imines and related tricyclic heterocycles by SNAr-type C-S, C-N, or C-O bond formation with heterocumulenes
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(Chemical Equation Presented) A simple and practical synthetic method of pyrimido[1,2-c]-[1,3]benzothiazin-6-imines and related tricyclic heterocycles has been developed. Treatment of 2-(2-haloaryl)-tetrahydropyrimidines with NaH and a heterocumulene such as carbon disulfide, isothiocyanates, and isocyanates in DMF provides the desired cyclization products through a regioselective S NAr-type reaction. This method provides direct access to PD 404182 and related compounds.
- Mizuhara, Tsukasa,Oishi, Shinya,Fujii, Nobutaka,Ohno, Hiroaki
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supporting information; experimental part
p. 265 - 268
(2010/04/06)
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