120278-07-1

Basic information

• Product Name: 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
• Synonyms: 1-N-CBZ-4-AMINO-PIPERIDINE;4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER;4-AMINO-1-N-CBZ-PIPERIDINE;1-CBZ-4-AMINOPIPERIDINE;Benzyl 4-aminopiperidine-1-carboxylate;benzyl 4-aminopiperidine-1-carboxylate hydrochloride;N-CBZ-4-aMinepiperidin;1-Piperidinecarboxylic acid, 4-amino-, phenylmethyl ester
• CAS NO: 120278-07-1
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.29
• Mol File: 120278-07-1.mol

Chemical Properties

• Melting Point: 68 °C(dec.)
• Boiling Point: 367.235 °C at 760 mmHg
• Flash Point: 175.898 °C
• Appearance: /
• Density: 1.152 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.07±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(120278-07-1)
• EPA Substance Registry System: 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER(120278-07-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-37-60
• Hazardous Substances Data: 120278-07-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER is used as a key intermediate in organic synthesis for the development of various chemical compounds. Its unique structure allows for the creation of a wide range of products through chemical reactions, making it a valuable component in the synthesis of new molecules.
Used in Agrochemical Industry:
In the agrochemical field, 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER is used as a vital raw material for the production of pesticides and other agricultural chemicals. Its reactivity and functional groups enable the development of effective compounds that can protect crops from pests and diseases, thereby contributing to increased agricultural productivity.
Used in Pharmaceutical Industry:
4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER plays a significant role in the pharmaceutical industry as a building block for the synthesis of various drug molecules. Its presence in the molecular structure can impart specific biological activities, making it an essential component in the development of new medications for the treatment of various diseases.
Used in Dye Industry:
In the dyestuff industry, 4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER is utilized as an important intermediate for the synthesis of dyes and pigments. Its chemical properties allow for the creation of a diverse range of colorants that can be used in various applications, such as textiles, plastics, and printing inks, to impart vibrant colors and improve product aesthetics.

InChI:InChI=1/C13H18N2O2/c14-12-6-8-15(9-7-12)13(16)17-10-11-4-2-1-3-5-11/h1-5,12H,6-10,14H2

Upstream product

• 169814-97-5 phenylmethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-piperidinecarboxylate 
• 159874-20-1 1-benzyloxycarbonyl-4-tert-butoxycarbonylaminopiperidine 
• 95798-23-5 1-(benzyloxycarbonyl)-4-hydroxypiperidine 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 

Downstream Products

• 777946-41-5 4-(2-cyclohexylidene-2-fluoro-acetylamino)-piperidine-1-carboxylic acid benzyl ester 
• 959793-10-3 benzyl 4-carbamimidamidopiperidine-1-carboxylate 
• 72349-01-0 benzyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate 
• 1033843-48-9 Benzyl 4-({[6-(3-fluorophenyl)pyridin-3-yl]carbonyl}amino)piperidine-1-carboxylate 
• 1174020-66-6 C₁₈H₂₃N₃O₄ 
• 1220700-76-4 ethyl 4-({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)-6-quinolin-3-yl-1,5-naphthyridine-3-carboxylate 
• 1174020-67-7 tert-butyl (2S)-2-[({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)carbonyl]-5-oxopiperidine-1-carboxylate 
• 1174020-15-5 benzyl 4-{[1-(tert-butoxycarbonyl)-5-oxo-L-prolyl]amino}piperidinecarboxylate 
• 1401540-68-8 4-[({(2S,5S)-5-[(benzyloxy)amino]piperidin-2-yl}carbonyl)amino ]piperidine-1-carboxylic acid benzyl ester 
• 1174020-16-6 benzyl 4-({N-(tert-butoxycarbonyl)-6-[dimethyl(oxido)-λ(4)-sulfanylidene]-5-oxo-L-norleucyl}amino)piperidine-1-carboxylate 
• 1174020-17-7 tert-butyl (2S)-2-[({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)carbonyl]-5-oxopiperidine-1-carboxylate 
• 1174020-18-8 tert-butyl (2S,5S)-2-[({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)carbonyl]-5-({[4-(trifluoromethyl)phenyl]sulfonyl}oxy)piperidine-1-carboxylate 
• 1174020-21-3 4-({[(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-yl]carbonyl}amino)piperidine-1-carboxylic acid benzyl ester 
• 1174018-99-5 (2S,5R)-sulfuric acid mono{[(4-aminopiperidin-4-yl)carbonyl]-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl}ester 

Relevant articles and documents

Decarboxylative Amination: Diazirines as Single and Double Electrophilic Nitrogen Transfer Reagents

The ubiquity of nitrogen-containing small molecules in medicine necessitates the continued search for improved methods for C-N bond formation. Electrophilic amination often requires a disparate toolkit of reagents whose selection depends on the specific structure and functionality of the substrate to be aminated. Further, many of these reagents are challenging to handle, engage in undesired side reactions, and function only within a narrow scope. Here we report the use of diazirines as practical reagents for the decarboxylative amination of simple and complex redox-active esters. The diaziridines thus produced are readily diversifiable to amines, hydrazines, and nitrogen-containing heterocycles in one step. The reaction has also been applied in fluorous phase synthesis with a perfluorinated diazirine.

BETA-LACTAMASE INHIBITORS

Substituted bicyclic beta-lactams of Formula I: (I), are ?-lactamase inhibitors, wherein a, X, R1 and R2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with ?-lactam antibiotics. In particular, the compounds can be employed with a ?-lactam antibiotics (e.g., imipenem, piperacillin, or ceftazidime) against microorganisms resistant to ?-lactam antibiotics due to the presence of the ?-lactamases.

PROLYL HYDROXYLASE INHIBITORS

The invention described herein relates to certain pyrimidinetrione N-substituted glycine derivatives of formula (I), (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

THF-CONTAINING SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE

The present invention relates to a class of THF-containing sulfonamides which are aspartyl protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention.