1174020-16-6

Basic information

• Product Name: benzyl 4-({N-(tert-butoxycarbonyl)-6-[dimethyl(oxido)-λ(4)-sulfanylidene]-5-oxo-L-norleucyl}amino)piperidine-1-carboxylate
• Synonyms: benzyl 4-({N-(tert-butoxycarbonyl)-6-[dimethyl(oxido)-λ(4)-sulfanylidene]-5-oxo-L-norleucyl}amino)piperidine-1-carboxylate
• CAS NO: 1174020-16-6
• Molecular Weight: 537.678
• Mol File: 1174020-16-6.mol

Chemical Properties

• CAS DataBase Reference: benzyl 4-({N-(tert-butoxycarbonyl)-6-[dimethyl(oxido)-λ(4)-sulfanylidene]-5-oxo-L-norleucyl}amino)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-({N-(tert-butoxycarbonyl)-6-[dimethyl(oxido)-λ(4)-sulfanylidene]-5-oxo-L-norleucyl}amino)piperidine-1-carboxylate(1174020-16-6)
• EPA Substance Registry System: benzyl 4-({N-(tert-butoxycarbonyl)-6-[dimethyl(oxido)-λ(4)-sulfanylidene]-5-oxo-L-norleucyl}amino)piperidine-1-carboxylate(1174020-16-6)

Safety Data

• Hazardous Substances Data: 1174020-16-6(Hazardous Substances Data)

Upstream product

• 1174020-15-5 benzyl 4-{[1-(tert-butoxycarbonyl)-5-oxo-L-prolyl]amino}piperidinecarboxylate 
• 1774-47-6 trimethylsulfoxonium iodide 
• 98-79-3 L-Pyroglutamic acid 
• 1174020-66-6 C₁₈H₂₃N₃O₄ 
• 120278-07-1 benzyl 4-aminopiperidine-1-carboxylate 

Downstream Products

• 1174020-67-7 tert-butyl (2S)-2-[({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)carbonyl]-5-oxopiperidine-1-carboxylate 
• 1401540-68-8 4-[({(2S,5S)-5-[(benzyloxy)amino]piperidin-2-yl}carbonyl)amino ]piperidine-1-carboxylic acid benzyl ester 
• 1174020-17-7 tert-butyl (2S)-2-[({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)carbonyl]-5-oxopiperidine-1-carboxylate 
• 1174020-18-8 tert-butyl (2S,5S)-2-[({1-[(benzyloxy)carbonyl]piperidin-4-yl}amino)carbonyl]-5-({[4-(trifluoromethyl)phenyl]sulfonyl}oxy)piperidine-1-carboxylate 
• 1174020-21-3 4-({[(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-yl]carbonyl}amino)piperidine-1-carboxylic acid benzyl ester 
• 1174018-99-5 (2S,5R)-sulfuric acid mono{[(4-aminopiperidin-4-yl)carbonyl]-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl}ester 

Relevant articles and documents

A concise synthesis of a β-lactamase inhibitor

MK-7655 (1) is a β-lactamase inhibitor in clinical trials as a combination therapy for the treatment of bacterial infection resistant to β-lactam antibiotics. Its unusual structural challenges have inspired a rapid synthesis featuring an iridium-catalyzed N-H insertion and a series of late stage transformations designed around the reactivity of the labile bicyclo[3.2.1]urea at the core of the target.

BETA-LACTAMASE INHIBITORS

Substituted bicyclic beta-lactams of Formula I: (I), are ?-lactamase inhibitors, wherein a, X, R1 and R2 are defined herein. The compounds and pharmaceutically acceptable salts thereof are useful in the treatment of bacterial infections in combination with ?-lactam antibiotics. In particular, the compounds can be employed with a ?-lactam antibiotics (e.g., imipenem, piperacillin, or ceftazidime) against microorganisms resistant to ?-lactam antibiotics due to the presence of the ?-lactamases.