cas 120351-94-2, 3-(2-Aminoethoxy)benzonitrile | Articles data ｜lookchem

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120351-94-2

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SUBSTITUTED 2H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS GSK-3 INHIBITORS
The invention relates to compounds of formula (I) prodrugs thereof, and the pahrmaceutically acceptabel salts of the compounds and prodrugs, wherein Ra, Rb, R1 and R2 are as defined herein; pharmaceutical compositions thereof; and uses thereof.
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Page/Page column 33

(2010/02/11)

Design, synthesis, and SAR of monobenzamidines and aminoisoquinolines as factor Xa inhibitors
Monoamidine FXa inhibitors 3 were designed and synthesized. SAR studies and molecular modeling led to the design of conformationally constrained diaryl ethers 4 and 5, as well as benzopyrrolidinone 7 as potent FXa inhibitors. The monoamidines show high efficacy in a DVT model, but lack desirable oral bioavailability. The benzopyrrolidinone-based aminoisoquinolines 8 do not show significant improvement in oral bioavailability.
Zhang, Penglie,Zuckett, Jingmei F.,Woolfrey, John,Tran, Katherine,Huang, Brian,Wong, Paul,Sinha, Uma,Park, Gary,Reed, Andrea,Malinowski, John,Hollenbach, Stan,Scarborough, Robert M.,Zhu, Bing-Yan
p. 1657 - 1661
(2007/10/03)

BENZAMIDINE DERIVATIVES
Benzamidine derivatives of the following formulae or analogs thereof, i. e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of activated blood coagulation factor X, and they are useful as anticoagulants.
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(2008/06/13)

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Chemical Properties

Boiling Point: 303.009oC at 760 mmHg
Flash Point:137.055oC
Density: 1.135g/cm3
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
Vapor Pressure: 0.001mmHg at 25°C
PSA: 59.04000
LogP: 1.59608

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