120351-94-2

Basic information

• Product Name: 3-(2-Aminoethoxy)benzonitrile
• Synonyms: 3-(2-Aminoethoxy)benzonitrile;3-(2-Aminoethoxy)
• CAS NO: 120351-94-2
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.1885
• Mol File: 120351-94-2.mol

Chemical Properties

• Boiling Point: 303.009°C at 760 mmHg
• Flash Point: 137.055°C
• Appearance: /
• Density: 1.135g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 3-(2-Aminoethoxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Aminoethoxy)benzonitrile(120351-94-2)
• EPA Substance Registry System: 3-(2-Aminoethoxy)benzonitrile(120351-94-2)

Safety Data

• Hazardous Substances Data: 120351-94-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-(2-Aminoethoxy)benzonitrile is used as a chemical intermediate for the synthesis of drugs aimed at treating various medical conditions. Its unique structure allows it to be a building block in the creation of new pharmaceutical compounds, enhancing the industry's capacity to develop innovative treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(2-Aminoethoxy)benzonitrile serves as an intermediate in the production of agrochemicals, potentially contributing to the development of new pesticides, herbicides, or other agricultural chemicals that can improve crop protection and yield.
Used in Research Laboratories:
3-(2-Aminoethoxy)benzonitrile is also utilized as a research compound in laboratories, where it is employed as a building block for the synthesis of new chemical entities. Its presence in research settings facilitates the exploration of novel chemical reactions and the discovery of potential new applications in various fields.

InChI:InChI=1/C9H10N2O/c10-4-5-12-9-3-1-2-8(6-9)7-11/h1-3,6H,4-5,10H2

Upstream product

• 252263-98-2 3-[2-(tert-butoxycarbonylamino)ethoxy]benzonitrile 
• 873-62-1 m-cyanophenol 

Downstream Products

• 309930-31-2 2'-tert-butylsulfamoyl-biphenyl-4-carboxylic acid [2-(3-cyano-phenoxy)-ethyl]-amide 
• 476352-82-6 3-{2-[5-(2'-tert-butylaminosulfonyl)phenyl-1-oxoisoindolin-2-yl]ethoxy}benzonitrile 
• 476352-36-0 2'-sulfamoyl-biphenyl-4-carboxylic acid [2-(3-cyano-phenoxy)-ethyl]-methyl-amide 
• 476352-32-6 2'-sulfamoyl-biphenyl-4-carboxylic acid [2-(3-cyano-phenoxy)-ethyl]-amide 
• 476352-40-6 [[2-(3-cyano-phenoxy)-ethyl]-(2'-sulfamoyl-biphenyl-4-carbonyl)-amino]-acetic acid methyl ester 
• 476352-41-7 [[2-(3-cyano-phenoxy)-ethyl]-(2'-sulfamoyl-biphenyl-4-carbonyl)-amino]-acetic acid 
• 476352-37-1 2'-sulfamoyl-biphenyl-4-carboxylic acid benzyl-[2-(3-cyano-phenoxy)-ethyl]-amide 
• 476352-38-2 2'-sulfamoyl-biphenyl-4-carboxylic acid [2-(3-cyano-phenoxy)-ethyl]-pyridin-3-ylmethyl-amide 
• 111625-00-4 3-{2-[4-Cyano-5-methyl-4-(3,4,5-trimethoxy-phenyl)-hexylamino]-ethoxy}-benzonitrile 
• 477716-86-2 3-[2-(5-bromo-1,3-dioxoisoindolin-2-yl)ethoxy]benzonitrile 
• 210961-79-8 N-[2-(3-cyanophenoxy)ethyl]-4-cyanobenzamide 

Relevant articles and documents

SUBSTITUTED 2H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINES AS GSK-3 INHIBITORS

The invention relates to compounds of formula (I) prodrugs thereof, and the pahrmaceutically acceptabel salts of the compounds and prodrugs, wherein Ra, Rb, R1 and R2 are as defined herein; pharmaceutical compositions thereof; and uses thereof.

Design, synthesis, and SAR of monobenzamidines and aminoisoquinolines as factor Xa inhibitors

Monoamidine FXa inhibitors 3 were designed and synthesized. SAR studies and molecular modeling led to the design of conformationally constrained diaryl ethers 4 and 5, as well as benzopyrrolidinone 7 as potent FXa inhibitors. The monoamidines show high efficacy in a DVT model, but lack desirable oral bioavailability. The benzopyrrolidinone-based aminoisoquinolines 8 do not show significant improvement in oral bioavailability.

BENZAMIDINE DERIVATIVES

Benzamidine derivatives of the following formulae or analogs thereof, i. e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of activated blood coagulation factor X, and they are useful as anticoagulants.