252263-98-2

Basic information

• Product Name: 3-(Boc-aMinoethyloxy)benzonitrile
• Synonyms: 3-(Boc-aMinoethyloxy)benzonitrile
• CAS NO: 252263-98-2
• Molecular Formula: C₁₄H₁₈N₂O₃
• Molecular Weight: 262.30432
• Mol File: 252263-98-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 415.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.12±0.1 g/cm3(Predicted)
• PKA: 12.04±0.46(Predicted)
• CAS DataBase Reference: 3-(Boc-aMinoethyloxy)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Boc-aMinoethyloxy)benzonitrile(252263-98-2)
• EPA Substance Registry System: 3-(Boc-aMinoethyloxy)benzonitrile(252263-98-2)

Safety Data

• Hazardous Substances Data: 252263-98-2(Hazardous Substances Data)

Usage

General Description

3-(Boc-aminoethyloxy)benzonitrile is a chemical compound with the molecular formula C15H18N2O3. It is a benzyl protecting group that is commonly used in peptide synthesis to protect the amine group in amino acids. The compound features a Boc (tert-butoxycarbonyl) protecting group attached to the amino functional group, as well as a benzonitrile moiety. It is often utilized in the preparation of various pharmaceuticals and organic compounds, serving as a key building block in the synthesis of complex molecules. 3-(Boc-aMinoethyloxy)benzonitrile plays a crucial role in organic chemistry and drug development, due to its ability to selectively protect and modify specific functional groups within larger molecular structures.

Upstream product

• 873-62-1 m-cyanophenol 
• 39684-80-5 2-(tert-butoxycarbonylamino)ethyl bromide 
• 6952-59-6 3-cyanobromobenzene 
• 26690-80-2 2-(N-tert-butoxycarbonylamino)ethanol 
• 158690-56-3 2-(tert-butoxycarbonylamino)ethyl-4-methylbenzenesulfonate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 71999-74-1 tert-butyl N-(2-chloroethyl)carbamate 

Downstream Products

• 476352-38-2 2'-sulfamoyl-biphenyl-4-carboxylic acid [2-(3-cyano-phenoxy)-ethyl]-pyridin-3-ylmethyl-amide 
• 476352-37-1 2'-sulfamoyl-biphenyl-4-carboxylic acid benzyl-[2-(3-cyano-phenoxy)-ethyl]-amide 
• 476352-82-6 3-{2-[5-(2'-tert-butylaminosulfonyl)phenyl-1-oxoisoindolin-2-yl]ethoxy}benzonitrile 
• 476352-41-7 [[2-(3-cyano-phenoxy)-ethyl]-(2'-sulfamoyl-biphenyl-4-carbonyl)-amino]-acetic acid 
• 476352-40-6 [[2-(3-cyano-phenoxy)-ethyl]-(2'-sulfamoyl-biphenyl-4-carbonyl)-amino]-acetic acid methyl ester 
• 309930-31-2 2'-tert-butylsulfamoyl-biphenyl-4-carboxylic acid [2-(3-cyano-phenoxy)-ethyl]-amide 
• 476352-32-6 2'-sulfamoyl-biphenyl-4-carboxylic acid [2-(3-cyano-phenoxy)-ethyl]-amide 
• 476352-36-0 2'-sulfamoyl-biphenyl-4-carboxylic acid [2-(3-cyano-phenoxy)-ethyl]-methyl-amide 
• 210962-73-5 N-[2-(3-cyanophenoxy)ethyl]-4-(1-tert-butoxycarbonyl-4-piperidyloxy)benzamide 

Relevant articles and documents

Palladium Catalyzed C?O Coupling of Amino Alcohols for the Synthesis of Aryl Ethers

Amine containing aryl ethers are common pharmacophore motifs that continue to emerge from drug discovery efforts. As amino alcohols are readily available building blocks, practical methodologies for incorporating them into more complex structures are highly desirable. We report our efforts to explore the application of Pd-catalyzed C?O coupling methods to the arylation of 1,2- and 1,3-amino alcohols. We established general and reliable conditions, under which we explored the scope and limitations of the transformation. The insights gained have been valuable in employing this methodology within a fast-moving drug discovery environment, which we anticipate will be of general interest to the synthesis and catalysis communities.

Rational design, synthesis, and structure-activity relationships of novel factor Xa inhibitors: (2-substituted-4-amidinophenyl)pyruvic and -propionic acids

An inhibitor of factor Xa (fXa), the m-substituted benzamidine AXC1578 (1a), was structurally modified with the aim of increasing its potency. In particular, pyruvic acid and propionic acid substituents were incorporated into the P1 benzamidine moiety to

Benzamidine derivatives

Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.