- Palladium-catalyzed direct alkynylation of thiophenes with halosilylacetylenes
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Silylethynylthiophenes were obtained from palladium-catalyzed alkynylation of various thiophenes with 1-halo-2-silylacetylenes. The α-position of thiophenes was alkynylated with high regioselectivity. The terminal silyl groups of products could be replaced by several functional groups.
- Kato, Hayate,Tsukada, Naofumi
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supporting information
(2021/02/20)
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- Regiospecific palladium-catalyzed cross-coupling reactions using the operational equivalent of 1,3-dilithiopropyne
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A regiospecific palladium-catalyzed cross-coupling reaction using the operational equivalent of the dianion 1,3-dilithiopropyne, with aromatic iodides is reported. This reaction gives high yields of 1-propyn-1-yl-benzenes and 2-(propyn-1-yl)thiophenes in
- Cabezas, Jorge A.,Ferllini, Natasha
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p. 2387 - 2394
(2020/09/09)
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- Photochemical Synthesis of Bithienyl Derivatives
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The application of a photochemical arylation of thienyl derivatives to the synthesis of bithienyl compounds is reported.The syntheses of 5-phenyl-2-propynylthiophene and 5-but-3-en-1-ynyl-2,2'-bithienyl are described using as starting materials a phenylthienyl and a bithienyl derivative obtained by this method.Furhtermore, the photochemical synthesis of halogenobithienyl ketones via the photochemical coupling of a halogenothiophene and 2-acetyl-5-iodothiophene is describred.This methodology furnishes a new approach to the synthesis of natural bithienyls.All the synthesized compounds are singlet oxygen photosensitizers, and are, therefore, potentially bioactive compounds.
- D'Auria, Maurizio,Mico, Antonella De,D'Onofrio, Franco,Piancatelli, Giovanni
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p. 1777 - 1780
(2007/10/02)
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- NATURALLY-OCCURRING ACETYLENIC COMPOUNDS AND DERIVATIVES REGIO-AND STEREOCONTROLLED CHLOROFORMYLATION OF 2-(1-PROPYNYL)THIOPHENE AND 2-PHENYL-5-(1-PROPYNYL)THIOPHENE
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2-Phenyl-5-(1-propynyl)thiophene (1), isolated from Coreopsis grandiflora, and 2-(1-propynyl)thiophene (5), an immediate precursor in the synthesys of junipal (2), were synthesized in high yield by a Pd-catalyzed reaction between propyne and 2-iodo-5-phen
- Carpita, A.,Lezzi, A.,Rossi, R.,Marchetti, F.,Merlino, S.
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p. 621 - 626
(2007/10/02)
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