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Dimethyl sulfate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 77-78-1 Structure
  • Basic information

    1. Product Name: Dimethyl sulfate
    2. Synonyms: dimethylesterkyselinysirove;dimethylesterkyselinysirove(czech);dimethylmonosulfate;Dimethylsulfaat;Dimethylsulfat;dimethylsulfat(czech);Dimetilsolfato;DMS (Methyl sulfate)
    3. CAS NO:77-78-1
    4. Molecular Formula: C2H6O4S
    5. Molecular Weight: 126.13
    6. EINECS: 201-058-1
    7. Product Categories: Pharmaceutical Intermediates;Miscellaneous Reagents, Sulfur & Selenium Compounds
    8. Mol File: 77-78-1.mol
    9. Article Data: 19
  • Chemical Properties

    1. Melting Point: -32 °C
    2. Boiling Point: 188 °C(lit.)
    3. Flash Point: 182 °F
    4. Appearance: Clear colorless/Liquid
    5. Density: 1.333 g/mL at 25 °C(lit.)
    6. Vapor Density: 4.3 (vs air)
    7. Vapor Pressure: 0.7 mm Hg ( 25 °C)
    8. Refractive Index: n20/D 1.386(lit.)
    9. Storage Temp.: 2-8°C
    10. Solubility: ethanol: 0.26 g/mL, clear, colorless
    11. Water Solubility: 2.8 g/100 mL (18 ºC)
    12. Stability: Stable; combustible. Incompatible with strong oxidizing agents, strong bases including ammonia. Moisture-sensitive.
    13. Merck: 13,3282
    14. BRN: 635994
    15. CAS DataBase Reference: Dimethyl sulfate(CAS DataBase Reference)
    16. NIST Chemistry Reference: Dimethyl sulfate(77-78-1)
    17. EPA Substance Registry System: Dimethyl sulfate(77-78-1)
  • Safety Data

    1. Hazard Codes: T+
    2. Statements: 45-25-26-34-43-68
    3. Safety Statements: 53-45-61
    4. RIDADR: UN 1595 6.1/PG 1
    5. WGK Germany: 2
    6. RTECS: WS8225000
    7. F: 21
    8. HazardClass: 6.1(a)
    9. PackingGroup: I
    10. Hazardous Substances Data: 77-78-1(Hazardous Substances Data)

77-78-1 Usage

Chemical Description

Dimethyl sulfate is a colorless liquid used as a methylating agent.

Chemical Description

Dimethyl sulfate is a clear, colorless liquid that is used as a methylating agent in organic synthesis.

Chemical Description

Dimethyl sulfate is a methylating agent used to methylate the coumarins.

Chemical Description

Dimethyl sulfate is used to alkylate compounds 3c-e to form 1-alkyl(aryl)-3-methylimidazol-2-ones 4c-e.

Chemical Description

Dimethyl sulfate is a colorless, oily liquid that is used as a methylating agent.

Check Digit Verification of cas no

The CAS Registry Mumber 77-78-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 7 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 77-78:
(4*7)+(3*7)+(2*7)+(1*8)=71
71 % 10 = 1
So 77-78-1 is a valid CAS Registry Number.
InChI:InChI=1/C2H6O4S/c1-5-7(3,4)6-2/h1-2H3

77-78-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Detail
  • TCI America

  • (D0797)  Dimethyl Sulfate  >98.0%(GC)

  • 77-78-1

  • 25g

  • 190.00CNY

  • Detail
  • TCI America

  • (D0797)  Dimethyl Sulfate  >98.0%(GC)

  • 77-78-1

  • 500g

  • 290.00CNY

  • Detail

77-78-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name dimethyl sulfate

1.2 Other means of identification

Product number -
Other names Sulfuric acid, dimethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Dimethyl sulfate is used as a methylating agent in the manufacture of many organic chemicals. It is also used in the manufacture of dyes and perfumes, for the separation of mineral oils, and for the analysis of auto fluids. (-) Formerly, dimethyl sulfate was used as a war gas. (-4)
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:77-78-1 SDS

77-78-1Synthetic route

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

trimethyl phosphite
512-56-1

trimethyl phosphite

B

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With sulfur trioxide In dichloromethane at -50℃;A 7%
B 93%
methanol
67-56-1

methanol

7,12-epoxy-5,6,6a,7,12,12a-hexahydro-2-methoxybenz[a]anthracen-5-one

7,12-epoxy-5,6,6a,7,12,12a-hexahydro-2-methoxybenz[a]anthracen-5-one

A

2,5-dimethoxybenz[a]anthracene
1350749-76-6

2,5-dimethoxybenz[a]anthracene

B

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With sulfuric acid for 18h; Reflux; Inert atmosphere;A 88%
B n/a
phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

trimethyl phosphite
512-56-1

trimethyl phosphite

B

O,O,O-trimethylthiophosphate
152-18-1

O,O,O-trimethylthiophosphate

C

dimethyl sulfate
77-78-1

dimethyl sulfate

D

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

Conditions
ConditionsYield
With sulfur trioxide In dichloromethane at -78℃; Product distribution; other trialkyl phosphite,trialkyl phosphine, trialkyl arsines, trialkoxyarsines, var. molar ratio and temperatures;A 22%
B 4%
C 55%
D 19%
With sulfur trioxide In dichloromethane at -78℃;A 48%
B 16%
C 3%
D 9%
trimethylarsenite
6596-95-8

trimethylarsenite

A

dimethoxyarsenic methyl sulfate
80398-42-1

dimethoxyarsenic methyl sulfate

B

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With sulfur trioxide In dichloromethane at -50℃;A 39%
B 27%
trimethylarsenite
6596-95-8

trimethylarsenite

A

methoxyarsenic bis(methyl sulfate)
80398-43-2

methoxyarsenic bis(methyl sulfate)

B

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With sulfur trioxide In dichloromethane at -50℃;A 28%
B 38%
trimethylarsenite
6596-95-8

trimethylarsenite

A

arsenic tris(methyl sulfate)
80398-44-3

arsenic tris(methyl sulfate)

B

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With sulfur trioxide In dichloromethane at -50℃;A 19%
B 21%
trimethyl orthoformate
149-73-5

trimethyl orthoformate

A

Methyl formate
107-31-3

Methyl formate

B

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With sulfuric acid Etherification; Heating;A n/a
B 10%
dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With diethyl ether; sulfuric acid
methanol
67-56-1

methanol

methyl chlorosulfate
812-01-1

methyl chlorosulfate

A

methylene chloride
74-87-3

methylene chloride

B

methyl bisulfate
75-93-4

methyl bisulfate

C

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
at -15 - -10℃; und folgenden Destillieren unter vermindertem Druck;
methanol
67-56-1

methanol

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With chlorosulfonic acid at -15 - -10℃;
With sulfuric acid bei der Destillation;
With sulfuric acid anschliessend man destilliert das Reaktionsgemisch im Vakuum;
methyl nitrite
624-91-9

methyl nitrite

methyl chlorosulfate
812-01-1

methyl chlorosulfate

dimethyl sulfate
77-78-1

dimethyl sulfate

methyl nitrite
624-91-9

methyl nitrite

ethyl chlorosulfate
625-01-4

ethyl chlorosulfate

A

diethyl sulfate
64-67-5

diethyl sulfate

B

ethyl methane sulfate
814-40-4

ethyl methane sulfate

C

dimethyl sulfate
77-78-1

dimethyl sulfate

dimethylsulfite
616-42-2

dimethylsulfite

methyl chlorosulfate
812-01-1

methyl chlorosulfate

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
at 120 - 190℃;
dimethylsulfite
616-42-2

dimethylsulfite

methyl chlorosulfate
812-01-1

methyl chlorosulfate

A

methylene chloride
74-87-3

methylene chloride

B

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
at 120 - 190℃;
dimethylsulfite
616-42-2

dimethylsulfite

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With chlorine
With chlorine at 120 - 140℃;
methyl bisulfate
75-93-4

methyl bisulfate

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
bei der Destillation im Vakuum;
methyl bisulfate
75-93-4

methyl bisulfate

A

methyl chlorosulfate
812-01-1

methyl chlorosulfate

B

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With chlorosulfonic acid at 90 - 100℃;
ethyl methane sulfate
814-40-4

ethyl methane sulfate

A

diethyl sulfate
64-67-5

diethyl sulfate

B

dimethyl sulfate
77-78-1

dimethyl sulfate

Dimethyl ether
115-10-6

Dimethyl ether

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With sulfur trioxide
With sulfuric acid at 160℃; man leitet, erhitzt ist, und destilliert dann das Gemisch;
With sulfur trioxide Darstellung;
With sulfuric acid byproducts: H2O;
With H2SO4 byproducts: H2O;
methyl bisulfate
75-93-4

methyl bisulfate

methyl chloroformate
79-22-1

methyl chloroformate

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
at 60 - 100℃; reagiert analog mit Monoaethylsulfat;
at 60 - 100℃;
at 60 - 100℃;
2-(4-methylphenyl)-2,3-dimethyl-1,3-oxazolidine
78456-50-5

2-(4-methylphenyl)-2,3-dimethyl-1,3-oxazolidine

A

(2-hydroxyethyl)(methyl)amine
109-83-1

(2-hydroxyethyl)(methyl)amine

B

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With sodium hydroxide; acetic acid buffer In acetonitrile at 25℃; Rate constant; Mechanism; var. time, var. buffer, var. pH;
methyl p-toluene sulfonate
80-48-8

methyl p-toluene sulfonate

A

dimethyl disulfate
10506-59-9

dimethyl disulfate

B

p-toluenesulfonylanhydride
4124-41-8

p-toluenesulfonylanhydride

C

methyl 4-toluenepyrosulfonate
49829-22-3

methyl 4-toluenepyrosulfonate

D

C8H10O9S3
76443-13-5

C8H10O9S3

E

mixed anhydride of 4-toluenesulfonic acid and 4-toluenepyrosulfonic acid
76443-14-6

mixed anhydride of 4-toluenesulfonic acid and 4-toluenepyrosulfonic acid

F

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
With sulfur trioxide at 100℃; Product distribution; other temperature, other molar ratio of reagents;A n/a
B n/a
C 26.7 % Spectr.
D 4.5 % Spectr.
E n/a
F n/a
diethyl ether
60-29-7

diethyl ether

sulfuric acid
7664-93-9

sulfuric acid

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
reagiert analog mit Selensaeure;
alkaline earth salt of/the/ methylsulfuric acid

alkaline earth salt of/the/ methylsulfuric acid

dimethyl sulfate
77-78-1

dimethyl sulfate

lithium salt of/the/ methylsulfuric acid

lithium salt of/the/ methylsulfuric acid

dimethyl sulfate
77-78-1

dimethyl sulfate

methanol
67-56-1

methanol

oleum

oleum

dimethyl sulfate
77-78-1

dimethyl sulfate

Conditions
ConditionsYield
Darstellung;
2-Benzoxazolinone
59-49-4

2-Benzoxazolinone

dimethyl sulfate
77-78-1

dimethyl sulfate

3-methylbenzo[d]oxazol-2(3H)-one
21892-80-8

3-methylbenzo[d]oxazol-2(3H)-one

Conditions
ConditionsYield
Alkaline conditions;100%
With sodium hydroxide In water at 70 - 80℃; for 1h;90%
With sodium hydroxide for 0.5h;90%
Sesamol
533-31-3

Sesamol

dimethyl sulfate
77-78-1

dimethyl sulfate

5-methoxybenzo[d]1,3-dioxole
7228-35-5

5-methoxybenzo[d]1,3-dioxole

Conditions
ConditionsYield
With tetraethylammonium hydroxide at 0 - 20℃; for 1h;100%
With sodium hydroxide In water for 1h; Heating;99%
With potassium hydroxide
With potassium carbonate In acetone Heating; Yield given;
Alkaline conditions;
salicylaldehyde
90-02-8

salicylaldehyde

dimethyl sulfate
77-78-1

dimethyl sulfate

ortho-anisaldehyde
135-02-4

ortho-anisaldehyde

Conditions
ConditionsYield
With potassium carbonate In acetone100%
Stage #1: salicylaldehyde With sodium hydroxide In water
Stage #2: dimethyl sulfate In 1,4-dioxane; water at 70℃; for 0.0333333h; Temperature; Solvent; Concentration;
95.6%
With sodium hydroxide86%
4-Chloro-2-nitroaniline
89-63-4

4-Chloro-2-nitroaniline

dimethyl sulfate
77-78-1

dimethyl sulfate

4-chloro-N-methyl-2-nitroaniline
15950-17-1

4-chloro-N-methyl-2-nitroaniline

Conditions
ConditionsYield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In water; toluene at 20℃; Methylation;100%
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In water; toluene at 20℃;94%
2',4'-dihydroxypropiophenone
5792-36-9

2',4'-dihydroxypropiophenone

dimethyl sulfate
77-78-1

dimethyl sulfate

2-hydroxy-4-methoxypropiophenone
6270-44-6

2-hydroxy-4-methoxypropiophenone

Conditions
ConditionsYield
With potassium carbonate In acetone for 7h; Heating;100%
With potassium carbonate; benzene
With potassium carbonate In acetone Heating;
dimethylsulfide
75-18-3

dimethylsulfide

dimethyl sulfate
77-78-1

dimethyl sulfate

trimethylsulfonium methylsulfate
2181-44-4

trimethylsulfonium methylsulfate

Conditions
ConditionsYield
In acetonitrile Cooling with ice;100%
In acetone for 5h;75%
2,6-dimethylbenzoic acid
632-46-2

2,6-dimethylbenzoic acid

dimethyl sulfate
77-78-1

dimethyl sulfate

methyl 2,6-dimethylbenzoate
14920-81-1

methyl 2,6-dimethylbenzoate

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃;100%
With potassium carbonate In acetone at 20℃; for 4h;93%
With potassium hydroxide
With potassium carbonate at 25℃; for 1h;
rubiadin
117-02-2

rubiadin

dimethyl sulfate
77-78-1

dimethyl sulfate

1,3-dimethoxy-2-methylanthraquinone
22170-88-3

1,3-dimethoxy-2-methylanthraquinone

Conditions
ConditionsYield
With potassium carbonate In acetone for 22h; Reflux;100%
With potassium carbonate; acetone
3,5-dichlorophenol
591-35-5

3,5-dichlorophenol

dimethyl sulfate
77-78-1

dimethyl sulfate

3,5-dichloroanisole
33719-74-3

3,5-dichloroanisole

Conditions
ConditionsYield
With potassium carbonate In acetone for 3h;100%
With potassium carbonate In acetone for 3h; Ambient temperature;100%
With sodium hydroxide
2,4,6-trihydroxyacetophenone
480-66-0

2,4,6-trihydroxyacetophenone

dimethyl sulfate
77-78-1

dimethyl sulfate

2-hydroxy-4,6-dimethoxyacetophenone
90-24-4

2-hydroxy-4,6-dimethoxyacetophenone

Conditions
ConditionsYield
With potassium carbonate In acetone Inert atmosphere;100%
With potassium carbonate In acetone for 3h; Reflux;100%
With potassium carbonate In acetone at 66℃; for 2h; Inert atmosphere;100%
2,6-dimethyl-4-hydroxybenzaldehyde
70547-87-4

2,6-dimethyl-4-hydroxybenzaldehyde

dimethyl sulfate
77-78-1

dimethyl sulfate

4-methoxy-2,6-dimethylbenzylaldehyde
19447-00-8

4-methoxy-2,6-dimethylbenzylaldehyde

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 25℃; for 16h;100%
With sodium hydroxide In water at 10℃; for 2h;85%
With potassium hydroxide at 35℃;
4-hydroxysalicylic acid
89-86-1

4-hydroxysalicylic acid

dimethyl sulfate
77-78-1

dimethyl sulfate

methyl 2, 4-dimethoxybenzoate
2150-41-6

methyl 2, 4-dimethoxybenzoate

Conditions
ConditionsYield
With potassium carbonate100%
With potassium hydroxide at 50℃;
With potassium hydroxide
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 70 - 115℃; for 10.5h;
With potassium carbonate In acetone
2-methylbenzene-1,4-diol
95-71-6

2-methylbenzene-1,4-diol

dimethyl sulfate
77-78-1

dimethyl sulfate

2,5-dimethoxy toluene
24599-58-4

2,5-dimethoxy toluene

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 24h;100%
With potassium carbonate In butanone for 24h;94%
With potassium hydroxide In methanol for 8h; steam distillation;82%
1,3-dihydroxynaphthalene
132-86-5

1,3-dihydroxynaphthalene

dimethyl sulfate
77-78-1

dimethyl sulfate

1,3-dimethoxynaphthalene
10075-61-3

1,3-dimethoxynaphthalene

Conditions
ConditionsYield
With potassium carbonate In acetone100%
With potassium hydroxide
With potassium carbonate In acetone Heating;
With potassium carbonate In acetone
2,4,6-Triiodophenol
609-23-4

2,4,6-Triiodophenol

dimethyl sulfate
77-78-1

dimethyl sulfate

1,3,5-triiodo-2-methoxybenzene
63238-41-5

1,3,5-triiodo-2-methoxybenzene

Conditions
ConditionsYield
With potassium carbonate In acetonitrile Reflux; Inert atmosphere;100%
With potassium hydroxide
1-(2-hydroxy-4,6-dimethoxy-3-methyl-phenyl)-ethanone
23121-32-6

1-(2-hydroxy-4,6-dimethoxy-3-methyl-phenyl)-ethanone

dimethyl sulfate
77-78-1

dimethyl sulfate

2',4',6'-trimethoxy-3'-methylacetophenone
39701-13-8

2',4',6'-trimethoxy-3'-methylacetophenone

Conditions
ConditionsYield
With potassium carbonate In acetone100%
With potassium hydroxide
With potassium carbonate; acetone
2-bromo-5-nitrophenol
52427-05-1

2-bromo-5-nitrophenol

dimethyl sulfate
77-78-1

dimethyl sulfate

1-bromo-2-methoxy-4-nitrobenzene
77337-82-7

1-bromo-2-methoxy-4-nitrobenzene

Conditions
ConditionsYield
Stage #1: 2-bromo-5-nitrophenol With lithium hydroxide In tetrahydrofuran at 0℃; for 1h;
Stage #2: dimethyl sulfate at 20℃;
100%
With sodium hydroxide
2-iodo-3-nitrophenol
197243-48-4

2-iodo-3-nitrophenol

dimethyl sulfate
77-78-1

dimethyl sulfate

2-iodo-1-methoxy-3-nitrobenzene
98991-08-3

2-iodo-1-methoxy-3-nitrobenzene

Conditions
ConditionsYield
With tetraethylammonium bromide; sodium hydroxide In dichloromethane; water at 20℃; for 6h;100%
With sodium hydroxide
With potassium hydroxide Yield given;
dimethyl sulfate
77-78-1

dimethyl sulfate

2,3-naphthalenediol
92-44-4

2,3-naphthalenediol

2,3-dimethoxynaphthalene
10103-06-7

2,3-dimethoxynaphthalene

Conditions
ConditionsYield
With sodium hydroxide; triisooctyl amine In dichloromethane; water at 0℃; for 10h;100%
With sodium hydroxide In dichloromethane; water at 0℃; for 10h;100%
With potassium carbonate In acetone for 15h; Heating;94%
dimethyl sulfate
77-78-1

dimethyl sulfate

1-hydroxy-2-naphthoic acid
86-48-6

1-hydroxy-2-naphthoic acid

1-hydroxy-naphthalene-2-carboxylic acid methyl ester
948-03-8

1-hydroxy-naphthalene-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran for 1h; Methylation; esterification; Heating;100%
Stage #1: 1-hydroxy-2-naphthoic acid With lithium hydroxide In tetrahydrofuran for 0.5h;
Stage #2: dimethyl sulfate In tetrahydrofuran for 3h; Heating;
95.9%
Stage #1: 1-hydroxy-2-naphthoic acid With triethylamine In acetone for 0.25h; Inert atmosphere;
Stage #2: dimethyl sulfate In acetone at 55℃; for 12h; Inert atmosphere;
95%
dimethyl sulfate
77-78-1

dimethyl sulfate

Methyl fluoride
593-53-3

Methyl fluoride

Conditions
ConditionsYield
With potassium fluoride In water at 100℃; for 5h; Solvent; Reagent/catalyst; Temperature;100%
With potassium fluoride In water at 100℃; under 1125.11 Torr; for 5h; Reagent/catalyst; Solvent; Temperature;100%
With potassium fluoride In sulfolane at 100℃; under 750.075 Torr; for 0.166667h; Solvent; Temperature; Autoclave;92%
With potassium fluoride
With sodium fluoride In sulfolane
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

dimethyl sulfate
77-78-1

dimethyl sulfate

(methoxymethylidene)dimethylammonium methyl sulfate
21511-55-7, 34643-89-5

(methoxymethylidene)dimethylammonium methyl sulfate

Conditions
ConditionsYield
at 80℃; for 2h; Schlenk technique; Inert atmosphere;100%
at 20 - 80℃; Inert atmosphere;100%
In neat (no solvent) at 20 - 80℃; Inert atmosphere;100%
diethyl (2R,3R)-tartrate
87-91-2

diethyl (2R,3R)-tartrate

dimethyl sulfate
77-78-1

dimethyl sulfate

(+)-(2R,3R)-diethyl di-O-methyltartrate
27957-93-3

(+)-(2R,3R)-diethyl di-O-methyltartrate

Conditions
ConditionsYield
With sodium hydride In diethyl ether at 0 - 20℃; Inert atmosphere;100%
With sodium hydride In diethyl ether at 0 - 20℃; Inert atmosphere;100%
With sodium hydride In diethyl ether at 0 - 20℃;100%
With sodium hydride In diethyl ether
3,6-dimethylnaphthalene-1,8-diol
945-40-4

3,6-dimethylnaphthalene-1,8-diol

dimethyl sulfate
77-78-1

dimethyl sulfate

1,8-dimethoxy-3,6-dimethylnaphthalene

1,8-dimethoxy-3,6-dimethylnaphthalene

Conditions
ConditionsYield
With potassium carbonate In acetone for 32h; Inert atmosphere; Reflux;100%
With potassium carbonate In acetone
With potassium carbonate In acetone for 32h; Inert atmosphere; Reflux;
1,3,4-thiadiazole
289-06-5

1,3,4-thiadiazole

dimethyl sulfate
77-78-1

dimethyl sulfate

3-Methyl-1,3,4-thiadiazolium-methylsulfat
114395-38-9

3-Methyl-1,3,4-thiadiazolium-methylsulfat

Conditions
ConditionsYield
In dichloromethane for 0.5h; Heating;100%
4-morpholinecarboxaldehyde
4394-85-8

4-morpholinecarboxaldehyde

dimethyl sulfate
77-78-1

dimethyl sulfate

4-(Methoxymethylene)-morpholinium methyl sulfate
5780-15-4

4-(Methoxymethylene)-morpholinium methyl sulfate

Conditions
ConditionsYield
at 60 - 70℃; for 3h;100%
at 70℃; for 2h;
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

dimethyl sulfate
77-78-1

dimethyl sulfate

5-chloro-2-(methylamino)benzophenone
1022-13-5

5-chloro-2-(methylamino)benzophenone

Conditions
ConditionsYield
With sodium hydroxide; tetrabutylammomium bromide In tetrahydrofuran at 60℃; for 1h;100%
With sodium hydroxide; tetrabutylammomium bromide; potassium carbonate In tetrahydrofuran at 30 - 35℃; for 2.5h;96%
2,5-bis(1,3-benzodithiol-2-yl)pyrrole
58488-39-4

2,5-bis(1,3-benzodithiol-2-yl)pyrrole

dimethyl sulfate
77-78-1

dimethyl sulfate

2,5-bis(1,3-benzodithiol-2-yl)-1-methylpyrrole
153850-73-8

2,5-bis(1,3-benzodithiol-2-yl)-1-methylpyrrole

Conditions
ConditionsYield
With sodium hydroxide; tetraethylammonium bromide In dichloromethane Heating;100%
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

dimethyl sulfate
77-78-1

dimethyl sulfate

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

Conditions
ConditionsYield
With nitrogen at 80℃; for 2h;100%
With sodium 1.) 3 h, 60-80 degC: 2.) 0 degC, methanol; Yield given. Multistep reaction;
at 60℃; for 3h;
5-hydroxy-2,2-dimethyl-2H-chromene-6-carbaldehyde
54287-99-9

5-hydroxy-2,2-dimethyl-2H-chromene-6-carbaldehyde

dimethyl sulfate
77-78-1

dimethyl sulfate

5-(methoxy)-2,2-dimethyl-2H-chromene-6-carbaldehyde
79571-17-8

5-(methoxy)-2,2-dimethyl-2H-chromene-6-carbaldehyde

Conditions
ConditionsYield
With potassium carbonate In acetone at 20℃; for 20h; Inert atmosphere;100%
With potassium carbonate In acetone at 20℃; for 20h; Inert atmosphere;100%
With potassium carbonate In acetone at 20℃;100%
With potassium carbonate In acetone for 1h; Heating;52 mg
With potassium carbonate In acetone at 20℃; for 20h; Inert atmosphere;1.5 g

77-78-1Relevant articles and documents

Synthesis method of quaternary ammonium salt

-

Paragraph 0029; 0031; 0032, (2018/11/04)

The invention belongs to the technical field of preparation of chemicals and discloses a synthesis method of quaternary ammonium salt. The synthesis method comprises the following steps of: firstly reacting (CH3)2CO3 with H2SO4 to prepare (CH3)2SO4, then adding RN(CH3)2 to carry out quaternization reaction to prepare RN+(CH3)3O-SO2OCH3. The synthesis method disclosed by the invention has the advantages that generally, the one-pot reaction method is used and no solvent is used; by control of the feeding ratio, the reaction temperature and reaction substrate, the purity of the prepared quaternary ammonium salt is higher, and no residue of dimethyl sulfate and solvents is generated, so that the hazard of highly-toxic raw materials used in the traditional method to the environment and human isavoided; the synthesis method of the quaternary ammonium salt does not need reaction in the organic solvent, so that the production cost is reduced.

Understanding and control of dimethyl sulfate in a manufacturing process: Kinetic modeling of a fischer esterification catalyzed by H2SO 4

Guzowski Jr., John P.,Delaney, Edward J.,Humora, Michael J.,Irdam, Erwin,Kiesman, William F.,Kwok, Albert,Moran, Amy D.

body text, p. 232 - 239 (2012/06/18)

The formation and fate of monomethyl sulfate (MMS) and dimethyl sulfate (DMS) were studied by proton NMR for a sulfuric acid catalyzed esterification reaction in methanol. The kinetic rate constants for DMS and MMS were determined at 65 °C by fitting time-dependent experimental data to a model using DynoChem. In refluxing methanol, sulfuric acid was converted to monomethyl sulfate (MMS) in nearly quantitative yield within 45 min. Once formed, the MMS underwent a reversible esterification reaction to form DMS. Dimethylsulfate reacted with methanol to regenerate MMS and form dimethyl ether. A byproduct of the esterification reaction was water, which further consumed DMS through hydrolysis. On the basis of derived rate constants, in refluxing methanol, DMS would not be expected to exceed 4 ppm in the reaction mixture at equilibrium. In the presence of the carboxylic acid substrate, DMS was not detected in the reaction mixture. The reaction pathways of this system have been systematically investigated, and the results of this study will be presented.

A convergent approach to polycyclic aromatic hydrocarbons

Guignard, Raphael F.,Zard, Samir Z.

supporting information; experimental part, p. 12185 - 12187 (2011/12/15)

A new concise route to Polycyclic Aromatic Hydrocarbons (PAHs) through radical addition and cyclisation of xanthates is described. The Royal Society of Chemistry 2011.

Cu(II)-mediated methylthiolation of aryl C-H bonds with DMSO

Chu, Lingling,Yue, Xuyi,Qing, Feng-Ling

supporting information; scheme or table, p. 1644 - 1647 (2010/06/16)

(Figure Presented) An unprecedented Cu(II)-mediated methylthiolation of aryl C-H bonds under oxidative conditions that employs the widely available DMSO as the methylthiolation reagent is described. Various functional groups in the substrates were tolerat

Additives and products including oligoesters

-

, (2008/06/13)

The present invention relates to oligoesters and their use or the creation of additives. Oligoester containing additives and/or oligoesters themselves may be used for formulating pharmaceutical preparations, cosmetics or personal care products such as shampoos and conditioners. These oligoesters are particularly useful for the creation of multi-purpose additives that can impart conditioning, long substantivity and/or UV protection. Individual oligoesters and oligoester mixtures are described.

Novel processes for the preparation of adenosine compounds and intermediates thereto

-

, (2008/06/13)

Novel processes for the preparation of adenosine compounds and intermediates thereto. The adenosine compounds prepared by the present processes may be useful as cardiovascular agents, more particularly as antihypertensive and anti-ischemic agents, as cardioprotective agents which ameliorate ischemic injury or myocardial infarct size consequent to myocardial ischemia, and as an antilipolytic agents which reduce plasma lipid levels, serum triglyceride levels, and plasma cholesterol levels. The present processes may offer improved yields, purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.

α-aminoboronic acids prepared by novel synthetic methods

-

, (2008/06/13)

The present invention relates to a novel class of α-aminoboronic acids of Formula (V), which are useful as intermediates in synthetic processes for inhibitors of the serine proteases, leukocyte elastase, pancreatic elastase, cathepsin G, and chymotrypsin. More specifically, the α-aminoboronic acids are useful as intermediates for the synthesis of Hepatitis C Virus (HCV) protease inhibitors. This invention also generally relates to novel methods for the preparation of α-aminoboronic acids.

Kinetics and mechanism of oxidation of dimethylsulfoxide by N-halosulfonamides in water-methanol and water-acetic acid media

Thimme Gowda,Nambiar,D'Souza

, p. 403 - 406 (2007/10/03)

Kinetics of oxidation of dimethylsulfoxide (DMSO) by N-halosulfonamides (chloramine-B, chloramine-T, dichloramine-B and dichloramine-T) have been studied in 1 : 1 (v/v) water-methanol and water-acetic acid media in the presence of perchloric acid. The rates show first order kinetics in [oxidant], fractional to first order in [DMSO] and zero order in [H+]. Variation in ionic strength of the reaction medium or addition of the reduced products of oxidants has no significant effect on the rates of oxidations. But the rates decrease with decrease in dielectric constant of the reaction medium by increasing the methanol or acetic acid composition of the solvent. Two-pathway as well as Michaelis-Menten type mechanisms have been considered to explain the observed results. The activation parameters have also been computed.

Uptake of methanol vapor in sulfuric acid solutions

Kane, Scan M.,Leu, Ming-Taun

, p. 1411 - 1415 (2007/10/03)

The uptake of gas-phase methanol by liquid sulfuric acid has been investigated over the composition range of 40-85 wt% H2SO4 and the temperature range of 210-235 K. Laboratory studies were performed with a flow-tube reactor coupled to an electron-impact ionization mass spectrometer to detect trace gases. While reversible uptake was the primary mechanism at low acid concentrations, an irreversible reaction between methanol and sulfuric acid at low temperatures, forming methyl hydrogen sulfate and dimethyl sulfate, was observed at all concentrations. At compositions >65 wt% H2SO4, more than 90% of uptake was found to be reactive. On the basis of the uptake data and the calculated liquid-phase diffusion coefficients, the product of the effective Henry's law constant (H*) and the square root of the overall liquid-phase reaction rate (k1) was calculated as a function of acid concentration and temperature. The results suggest that the reaction with sulfuric acid forming methyl hydrogen sulfate and dimethyl sulfate is the dominant loss mechanism of methanol and that the oxidation of methanol is only a minor source of hydroxyl radicals in the upper troposphere.

Ester compounds

-

, (2008/06/13)

An ester compound represented by the formula: wherein R is a hydrogen atom, a C1-C3 alkyl group unsubstituted or substituted with one or more halogen atoms, an allyl group unsubstituted or substituted with one or more halogen atoms, or a propargyl group unsubstituted or substituted with one or more halogen atoms; and X is a hydrogen atom, a halogen atom, a C1-C3 alkyl group unsubstituted or substituted with one or more halogen atoms, a C2-C3 alkenyl group unsubstituted or substituted with one or more halogen atoms, a C2-C3 alkynyl group unsubstituted or substituted with one or more halogen atoms, a C1-C3 alkoxy group unsubstituted or substituted with one or more halogen atoms, a C1-C3 alkylthio group unsubstituted or substituted with one or more halogen atoms, or a C1-C3 alkoxymethyl group containing a C1-C3 alkoxy group unsubstituted or substituted with one or more halogen atoms, has an excellent pest-controlling effect.

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