- Scalable Approach to Fluorinated Heterocycles with Sulfur Tetrafluoride (SF4)
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A general approach to fluorinated (hetero)aromatic derivatives is elaborated. The key reaction is a deoxofluorination of substituted acetophenones with sulfur tetrafluoride (SF4). In contrast to previous deoxofluorination methods, this transformation is fast, scalable (up to 70 g), and high-yielding. More than 100 novel or previously hardly accessible fluorinated heterocycles, interesting for medicinal chemistry and agrochemistry, were synthesized.
- Trofymchuk, Serhii,Bugera, Maksym,Klipkov, Anton A.,Ahunovych, Volodymyr,Razhyk, Bohdan,Semenov, Sergey,Boretskyi, Andrii,Tarasenko, Karen,Mykhailiuk, Pavel K.
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p. 12181 - 12198
(2021/09/13)
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- Anti-tumor drug having multiple kinase inhibition and preparation method and application thereof
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The invention discloses an anti-tumor drug having multiple kinase inhibition and a preparation method and application thereof; a compound of formula (I) or its medicinal salt, wherein R1 is hydrogen atom, C1-6 is alkyl, halogenated C1-6 alkyl, halogen, or
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Paragraph 0057; 0058; 0059; 0060; 0061
(2018/09/12)
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- CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS
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Provided are cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer are also provided.
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Paragraph 0418; 0419
(2015/07/22)
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- PYRROLONE DERIVATIVES AS HERBICIDES
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The invention relates to pyrrolone compounds of the formula (I) wherein X, R1, R2, R3 and A are as defined in the specification. Furthermore, the present invention relates to processes and intermediates for making compounds of formula (I), to herbicidal compositions comprising these compounds and to methods of using these compounds to control plant growth.
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Page/Page column 52
(2015/02/25)
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- PYRAZOLYL PYRROLINONES AND THEIR USE AS HERBICIDES
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The invention relates to pyrrolone compounds of the formula (I) wherein X, R1, R2, R3 and A are as defined in the specification. Furthermore, the present invention relates to processes and intermediates for making compounds of formula (I), to herbicidal compositions comprising these compounds and to methods of using these compounds to control plant growth.
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Page/Page column 59; 6
(2015/02/25)
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- CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS
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Provided are cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer are also provided.
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Page/Page column 90; 91
(2014/01/17)
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- PTERIDINES AND THEIR USE AS AGROCHEMICALS
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The present disclosure relates to 1- or 2-(4-(aryloxy)-phenyl)ethylamino-, oxy- or sulfanyl)pteridines and 1- or 2-(4-(heteroaryloxy)-phenyl)ethylamino-, oxy- or sulfanyl)pteridines and their use as agrochemicals and animal health products.
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Page/Page column 22
(2011/04/14)
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- PTERIDINES AND THEIR USE AS AGROCHEMICALS
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The present disclosure relates to 1- or 2-(4-(aryloxy)-phenyl)ethylamino-, oxy- or sulfanyl)pteridines and 1- or 2-(4-(heteroaryloxy)-phenyl)ethylamino-, oxy- or sulfanyl)pteridines and their use as agrochemicals and animal health products.
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Page/Page column 50-51
(2011/04/14)
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- 5,8-DIFLUORO-4-(2-(4-(HETEROARYLOXY)-PHENYL)ETHYLAMINO)QUINAZOLINES AND THEIR USE AS AGROCHEMICALS
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The present disclosure relates to 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals and animal health products.
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Page/Page column 49
(2010/04/06)
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