1204298-58-7

Basic information

• Product Name: 1-Boc-3-aminoindazole
• Synonyms: 1-Boc-3-aminoindazole;tert-Butyl 3-aMino-1H-indazole-1-carboxylate
• CAS NO: 1204298-58-7
• Molecular Formula: C₁₂H₁₅N₃O₂
• Molecular Weight: 233.2664
• EINECS: 604-604-1
• Product Categories: Building Blocks;Indazole
• Mol File: 1204298-58-7.mol

Chemical Properties

• Boiling Point: 395.3±34.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.97±0.50(Predicted)
• CAS DataBase Reference: 1-Boc-3-aminoindazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-aminoindazole(1204298-58-7)
• EPA Substance Registry System: 1-Boc-3-aminoindazole(1204298-58-7)

Safety Data

• Hazardous Substances Data: 1204298-58-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Boc-3-aminoindazole is utilized as a key intermediate in the synthesis of biologically active molecules, playing a crucial role in the development of new drugs. Its protective Boc group allows for selective reactions, facilitating the creation of complex molecular structures that are otherwise challenging to achieve.
Used in Medicinal Chemistry Research:
As a building block in organic synthesis, 1-Boc-3-aminoindazole is employed for the preparation of pharmaceuticals and functional materials. Its versatility in reacting with various compounds makes it an indispensable tool for researchers in medicinal chemistry, aiding in the discovery and optimization of drug candidates.
Used in Drug Discovery:
1-Boc-3-aminoindazole is leveraged in drug discovery processes due to its potential to contribute to the creation of novel therapeutic agents. Its presence in the synthesis of biologically active molecules underscores its importance in advancing the field of medicinal chemistry, particularly in the invention of new pharmaceutical entities.

Upstream product

• 870-46-2 t-butoxycarbonylhydrazine 
• 4387-36-4 2-iodobenzonitrile 
• 2042-37-7 o-cyanobromobenzene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 874-05-5 3-aminoindazole 

Relevant articles and documents

Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy

We synthesized a library of aminopyrazole analogs to systematically explore the hydrophobic pocket adjacent to the hinge region and the solvent exposed region of cyclin dependent kinases. Structure-activity relationship studies identified an optimal substitution for the hydrophobic pocket and analog 24 as a potent and selective CDK2/5 inhibitor.

ARYL- AND HETARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDES AND USE THEREOF

The present application relates to novel aryl- and hetaryl-substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.

Assembly of substituted 3-aminoindazoles from 2-bromobenzonitrile via a CuBr-catalyzed coupling/condensation cascade process

CuBr-catalyzed coupling reaction of 2-halobenzonitriles with hydrazine carboxylic esters and CuBr/4-hydroxy-l-proline-catalyzed coupling reaction of 2-bromobenzonitriles with N′-arylbenzohydrazides proceed smoothly at 60-90 C to provide substituted 3-aminoindazoles through a cascade coupling/condensation (or coupling/deacylation/condensation) process. A wide range of 3-aminoindazoles with substituents at both the 1-position and the phenyl ring part can be prepared from the corresponding coupling partners.