1-Boc-3-aminoindazole

Base Information

• Chemical Name: 1-Boc-3-aminoindazole
• CAS No.: 1204298-58-7
• Molecular Formula: C12H15N3O2
• Molecular Weight: 233.2664
• Hs Code.: 2933990090
• Mol file: 1204298-58-7.mol

Synonyms:1-Boc-3-aminoindazole;tert-Butyl 3-aMino-1H-indazole-1-carboxylate

Chemical Property of 1-Boc-3-aminoindazole

Chemical Property:

• Boiling Point: 395.3±34.0 °C(Predicted)
• PKA: 0.97±0.50(Predicted)
• PSA: 70.87000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 2.33180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-Amino-1H-indazole-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-3-aminoindazole

There total 3 articles about 1-Boc-3-aminoindazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

t-butoxycarbonylhydrazine (870-46-2) + 2-iodobenzonitrile (4387-36-4) → tert-butyl 3-amino-1H-indazole-1-carboxylate (1204298-58-7)

Guidance literature:

With copper(l) iodide; potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 56h; Temperature; Time; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;

DOI:10.1021/jo400071h

Reference yield: 77.0%

t-butoxycarbonylhydrazine (870-46-2) + o-cyanobromobenzene (2042-37-7) → tert-butyl 3-amino-1H-indazole-1-carboxylate (1204298-58-7)

Guidance literature:

With potassium carbonate; copper(I) bromide; In dimethyl sulfoxide; at 80 ℃; for 12h; Temperature; Time; Reagent/catalyst; Solvent; Schlenk technique; Inert atmosphere;

DOI:10.1021/jo400071h

Reference yield: 48.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-aminoindazole (874-05-5) → tert-butyl 3-amino-1H-indazole-1-carboxylate (1204298-58-7)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 1.5h;

upstream raw materials:

t-butoxycarbonylhydrazine

2-iodobenzonitrile

o-cyanobromobenzene

di-tert-butyl dicarbonate