- PRODRUG MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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Paragraph 00248; 00251
(2020/05/19)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 144-145
(2019/05/22)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 140
(2017/12/13)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 129
(2017/12/14)
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- MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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Page/Page column 296
(2017/12/14)
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- PYRAZOLE AMIDE DERIVATIVE
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The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.
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Page/Page column 199
(2015/09/28)
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- COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS
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Compounds of formula (I) can modulate the activity of one or more S1P receptors and/or the activity of autotaxin (ATX).
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Page/Page column 147
(2014/02/16)
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- PROCESS FOR PRODUCTION OF BICYCLOY2.2.2¨OCTYLAMINE DERIVATIVE
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The present invention herein provides a process for production or a bicyclo[2.2.2]octylamine derivative which may be used as an intermediate for preparation of medical and pharmaceutical products. The process is quite efficient and can produce the derivative in a large-scale while using mild reaction conditions. The process for producing a bicyclo[2.2.2]octylamine derivative comprises the steps of subjecting, to ring-formation, a compound represented by the following general formula (1): [wherein R1 represents an alkyl group having 1 to 6 carbon atoms, which may have a substituent; an arylmethyl group which may have a substituent; or an arylethyl group which may have a substituent], and a compound represented by the following general formula (2): ????????R2-NH2?????(2) [wherein R2 represents an alkyl group having 1 to 6 carbon atoms, which may have a substituent; an aralkyl group which may have a substituent; a hydroxyl group; an alkyloxy group having 1 to 6 carbon atoms, which may have a substituent; or an aralkyloxy group which may have a substituent], and then reducing the resulting product.
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Page/Page column 17
(2011/06/10)
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