120821-89-8Relevant articles and documents
Direct C2-alkylation of azoles with alcohols and ethers through dehydrogenative cross-coupling under metal-free conditions
He, Tao,Yu, Lin,Zhang, Lei,Wang, Lei,Wang, Min
, p. 5016 - 5019 (2011)
A metal-free novel, simple, and highly efficient method for the direct C2-alkylation of azoles with alcohols and ethers has been developed on the basis of an oxidative C-H activation process. The dehydrogenative C-C cross-coupling reactions of R-position
Visible light-induced hydroxyalkylation of 2H-benzothiazoles with alcohols via selectfluor oxidation
Kong, Yaolei,Xu, Wenxiu,Liu, Xinghai,Weng, Jianquan
, p. 3245 - 3249 (2020)
A visible-light induced metal-free approach was described for the hydroxyalkylation of 2H-benzothiazoles with alcohols by using selectfluor as the oxidant. A variety of 2H-benzothiazoles and alcohols could be tolerated, providing a mild and simple method for the synthesis of C2-hydroxyalkylated 2H-benzothiazoles in moderate to good yields. Besides, ethers were also compatible in this reaction, leading to corresponding C2 ether-substituted 2H-benzothiazoles with high regioselectivity.
Direct α-Arylation of Alcohols with Aryl Halides through a Radical Chain Mechanism
Aoki, Kohei,Yonekura, Kyohei,Ikeda, Yuko,Ueno, Ryota,Shirakawa, Eiji
supporting information, p. 2200 - 2204 (2020/05/05)
Alcohols were found to be arylated directly at their α-C?H bond with aryl halides in the presence of a base and a substoichiometric amount of t-BuOOt-Bu through a homolytic aromatic substitution mechanism. (Figure presented.).
Preparation method of C2-substituted 2H-benzothiazole hydroxyalkylated derivative
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Paragraph 0022-0023, (2020/12/06)
The invention discloses a preparation method of a C2-substituted 2H-benzothiazole hydroxyalkylated derivative. The preparation method comprises the following steps: mixing substituted 2H-benzothiazolewith fatty alcohol, taking an organic dye photosensitizer as a catalyst, carrying out a normal-temperature stirring reaction in a solvent under the protection of nitrogen and the irradiation of an LED white light lamp, carrying out TLC monitoring until the reaction is finished, and carrying out separation and purification on a reaction solution to obtain the C2-substituted 2H-benzothiazole hydroxyalkylated derivative. By adopting the technology, a cheap and readily available organic dye is used as the catalyst, the new method for synthesizing the 2H-benzothiazole C2 hydroxyalkylated derivative through visible light induction is simple in catalytic system, mild in reaction condition, cheap and readily available in catalyst and good in yield.
Photocatalytic synthesis method of C2 substituted 2H-benzothiazole hydroxyalkylated derivative
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Paragraph 0034-0037, (2020/06/17)
The invention discloses a photocatalytic synthesis method of a C2 substituted 2H-benzothiazole hydroxyl alkylation derivative. The method comprises the following steps of: mixing substituted 2H-benzothiazole shown as a formula (II) with fatty alcohol shown as a formula (III), adding an oxidizing agent Selectfluor, an additive trifluoroacetic acid and a solvent acetonitrile, and carrying out a normal temperature stirring reaction under the protection of nitrogen and the irradiation of an LED blue light lamp; carrying out TLC monitoring until the reaction is finished, and carrying out separationand purification on the reaction liquid to obtain the C2-substituted 2H-benzothiazole hydroxyalkylated derivative represented by formula (I). The invention provides a new method for synthesizing the2H-benzothiazole C2 hydroxyalkylated derivative through visible light induction by taking Selectfluor as an oxidizing agent, trifluoroacetic acid as an additive and acetonitrile as a solvent. The method is simple in catalytic system, mild in reaction condition and wide in substrate range.
Application of substituted benzothiazole C2 hydroxyl alkylated derivative as bactericide
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Paragraph 0043-0046, (2019/11/12)
The invention discloses application of a substituted benzothiazole C2 hydroxyl alkylated derivative as a bactericide. The structural formula of the substituted benzothiazole C2 hydroxyl alkylated derivative is shown in the formula (I)(please see the specification for the formula); in the formula (I), R1 and R2 are independently selected from hydrogen or C1-C5 alkyl: H on a benzothiazole ring is mono substituted, multi substituted or not substituted by substituent R, and the C2 position of the benzothiazole ring is not substituted by R; n is an integer from 0-4, wherein the n represents numberof the R on the benzothiazole ring: when the n is equal to 0, the H on the benzothiazole ring is not substituted; when the n is equal to 1, the H on the benzothiazole ring is mono substituted by the R; when the n is equal to 2-4, the H on the benzothiazole ring is multi substituted by the R, and the substituent R on the different substituted positions is the same or different; and the substituentR is the hydrogen, the C1-C5 alkyl, C1-C2 alkoxy or halogen. According to the substituted benzothiazole C2 hydroxyl alkylated derivative, particular good inhibitory activity against wheat scab germs,corn southern leaf blight germs, cucumber anthracnose germs, rice sheath blight disease germs and other germs is provided.
Mild preparation method of substituted benzothiazole C2 hydroxyalkylated derivative
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Paragraph 0024-0025, (2019/11/29)
The invention discloses a mild preparation method of a substituted benzothiazole C2 hydroxyalkylated derivative. The preparation method comprises: mixing substituted benzothiazole represented by a formula (II) and a fatty alcohol represented by a formula (III), adding an oxidant K2S208 and water, carrying out a room temperature stirring reaction under the illumination of a LED white light lamp, monitoring by TLC until the reaction is completed, and separating and purifying the reaction solution to obtain the substituted benzothiazole C2 hydroxyalkylated derivative represented a formula (I). According to the present invention, the new method for synthesizing a substituted benzothiazole C2 hydroxyalkylated derivative in a water-containing system by using an inorganic peroxide K2S2O8 as an oxidant under the inducing with visible light is provided, and has advantages of high atomic economy, simple catalytic system, good product yield, wide substrate range and short reaction time.
General Reactivity of 2-Lithiobenzothiazole to Various Electrophiles and the Use as a Formyl Anion Equivalent in the Synthesis of α-Hydroxy Carbonyl Compounds
Chikashita, Hidenori,Ishibaba, Megumi,Ori, Keiji,Itoh, Kazuyoshi
, p. 3637 - 3648 (2007/10/02)
The reaction of 2-lithiobenzothiazole with a variety of electrophiles such as aldehydes, ketones, carboxylic esters, lactones, nitriles, and amides afforded the expected addition and substitution products.Trimethylsilyl chloride readily reacted with the b
