121041-43-8

Basic information

• Product Name: 3-Pyridazinamine, 6-(2-ethoxyphenoxy)-
• Synonyms: 3-Pyridazinamine, 6-(2-ethoxyphenoxy)-
• CAS NO: 121041-43-8
• Molecular Formula: C₁₂H₁₃N₃O₂
• Molecular Weight: 231.25052
• Mol File: 121041-43-8.mol

Chemical Properties

• Boiling Point: 440.9°Cat760mmHg
• Flash Point: 220.4°C
• Appearance: /
• Density: 1.221g/cm³
• Vapor Pressure: 5.69E-08mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 3-Pyridazinamine, 6-(2-ethoxyphenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridazinamine, 6-(2-ethoxyphenoxy)-(121041-43-8)
• EPA Substance Registry System: 3-Pyridazinamine, 6-(2-ethoxyphenoxy)-(121041-43-8)

Safety Data

• Hazardous Substances Data: 121041-43-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyridazinamine, 6-(2-ethoxyphenoxy)is used as a potential therapeutic agent for the treatment of cancer. Its antineoplastic and antiangiogenic properties make it a candidate for targeting cancer cells and disrupting the blood supply that supports tumor growth.
Used in Research and Development:
3-Pyridazinamine, 6-(2-ethoxyphenoxy)is used in scientific research to further understand its mechanisms of action and explore its potential medical uses. Further studies are needed to elucidate its pharmacological properties, efficacy, and safety profile, which will contribute to the advancement of cancer treatment options.
Used in Drug Discovery and Design:
3-Pyridazinamine, 6-(2-ethoxyphenoxy)serves as a starting point for drug discovery and design efforts. Its unique chemical structure and biological activities can be further optimized and modified to develop more potent and selective anticancer agents, potentially leading to the creation of novel therapeutics for various types of cancer and related diseases.

InChI:InChI=1/C12H13N3O2/c1-2-16-9-5-3-4-6-10(9)17-12-8-7-11(13)14-15-12/h3-8H,2H2,1H3,(H2,13,14)

Upstream product

• 94-71-3 2-Ethoxyphenol 
• 5469-69-2 6-chloro-pyridazin-3-ylamine 

Downstream Products

• 128863-59-2 6-(2'-ethoxyphenoxy)-3-methoxy-2-(3-nitrophenyl)imidazo<1,2-b>pyridazine 
• 128863-60-5 6-(2'-ethoxyphenoxy)-3-methoxy-2-(4-nitrophenyl)imidazo<1,2-b>pyridazine 
• 128863-58-1 6-(2'-ethoxyphenoxy)-3-methoxy-2-(4-methoxyphenyl)imidazo<1,2-b>pyridazine 
• 128863-70-7 3-ethoxy-6-(2'-ethoxyphenoxy)-2-(4-fluorophenyl)imidazo<1,2-b>pyridazine 
• 128863-61-6 2-(3'-aminophenyl)-6-(2-ethoxyphenoxy)-3-methoxyimidazo<1,2-b>pyridazine 
• 128863-56-9 6-(2'-ethoxyphenoxy)-2-(3-fluorophenyl)-3-methoxyimidazo<1,2-b>pyridazine 
• 128863-54-7 6-(2'-ethoxyphenoxy)-3-methoxy-2-(3-methylphenyl)imidazo<1,2-b>pyridazine 
• 128863-69-4 3-ethoxy-6-(2'-ethoxyphenoxy)-2-phenylimidazo<1,2-b>pyridazine 
• 128863-57-0 6-(2'-ethoxyphenoxy)-2-(4-fluorophenyl)-3-methoxyimidazo<1,2-b>pyridazine 
• 128863-62-7 2-(4'-aminophenyl)-6-(2-ethoxyphenoxy)-3-methoxyimidazo<1,2-b>pyridazine 
• 128863-55-8 6-(2'-ethoxyphenoxy)-3-methoxy-2-(4-methylphenyl)imidazo<1,2-b>pyridazine 
• 121040-60-6 6-(2'-ethoxyphenoxy)-3-methoxy-2-phenylimidazo<1,2-b>pyridazine 

Relevant articles and documents

Imidazopyridazines. VI. Syntheses and Central Nervous System Activities of Some 6-(Alkoxy- and methylthio-phenoxy and methoxybenzylthio)-3-methoxy-2-phenyl(substituted phenyl and pyridinyl)imidazopyridazines

Series of 6-(alkoxy- and methylthio-phenoxy)-2-phenyl(substituted phenyl and pyridinyl)imidazopyridazines and 3-methoxy-6-(methoxybenzylthio)-2-phenyl(substituted phenyl and pyridinyl)imidazopyridazines have been prepared and subsesquently tested for their ability to inhibit GABA-stimulated 3H-diazepam binding to rat brain plasma membranes.The 6-(alkoxy- and methylthio-phenoxy) and 6-(methoxybenzylthio) compounds were much more effective in the displacement studies than the parent 6-phenoxy or 6-benzylthio compounds respectively.3-Methoxy-6-(2'-methoxyphenoxy)-2-phenylimidazopyridazine (GBLD-167, IC50 70 nM) was 16 times more effective than its 3-methoxy-6-phenoxy analogue (GBLD-214, IC50 1120 nM) and the 3-methoxy-6-(2'-methoxybenzylthio)-2-phenyl compound (GBLD-163, IC50 9 nM) was two and a half times more active than its 6-benzylthio-3-methoxy analogue (GBLD-137, IC50 22nM).The most active member of the 6-phenoxy series was the 2-(4'-fluorophenyl)-3-methoxy-6-(2''-methoxyphenoxy) compound (GBLD-255, IC50 30nM) and, within the 6-benzylthio series, the 2-(4'-fluorophenyl, 3'-aminophenyl, and pyridin-3'-yl)-3-methoxy-6-(3''-methoxybenzylthio) compounds (GBLD-233, 301 and 296) all gave IC50 5nM.A Hansch-type analysis of the results for these two closely related series of compounds indicates that electron-donating substituents in 2-(para substituted phenyl) derivatives favour binding, but bulky substituents hinder this effect.