94-71-3

Basic information

• Product Name: 2-Ethoxyphenol
• Synonyms: 2-ethoxy-pheno;2-Ethyloxyphenol;Guaiethol;Phenol, o-ethoxy-;2-ETHOXYPHENOL;2-HYDROXYPHENETOLE;2-HYDROXYPHENYL ETHYL ETHER;1-HYDROXY-2-ETHOXYBENZENE
• CAS NO: 94-71-3
• Molecular Formula: C8H10O2
• Molecular Weight: 138.16
• EINECS: 202-358-5
• Product Categories: Phenol&Thiophenol&Mercaptan;Phenetole;Indazoles
• Mol File: 94-71-3.mol
• Article Data: 34

Chemical Properties

• Melting Point: 20-25 °C(lit.)
• Boiling Point: 216-217 °C(lit.)
• Flash Point: 91 °C
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.09 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.081mmHg at 25°C
• Refractive Index: n20/D 1.529(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: 9g/l
• PKA: pK1:10.109 (25°C)
• Water Solubility: 8.414g/L(24.99 oC)
• BRN: 1100453
• CAS DataBase Reference: 2-Ethoxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethoxyphenol(94-71-3)
• EPA Substance Registry System: 2-Ethoxyphenol(94-71-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39-37/39
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 94-71-3(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to yellow liquid

Uses

Different sources of media describe the Uses of 94-71-3 differently. You can refer to the following data:
1. 2-Ethoxyphenol is used in the studies on the inhibition of oral bacteria by phenolic compounds. Studies on the prostagladins cyclooxygenase inhibition by phenolic compounds. Reagent for the stereoselective preparation of (arylthiomethyl)morpholines as selective norepinephrine reuptake inhibitors and dual serotonin/norepinephrine reuptake inhibitors.
2. 2-Ethoxyphenol has been used as carbon and energy supplement in the growth medium of red-pigmented coryneform bacterium, Rhodococcus rhodochrous strain 116.

General Description

2-Ethoxyphenol is a smoke flavour compound and forms complexes with iron (III).

InChI:InChI=1/C8H10O2/c1-2-10-8-6-4-3-5-7(8)9/h3-6,9H,2H2,1H3

Upstream product

• 10467-10-4 ethylmagnesium iodide 
• 95-47-6 o-xylene 
• 860556-23-6 1-ethoxy-2-benzyloxy-benzene 
• 2050-46-6 1,2-diethoxybenzene 
• 17600-72-5 2-ethoxyanisole 
• 56-23-5 tetrachloromethane 
• 917-64-6 methyl magnesium iodide 
• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 90-05-1 2-methoxy-phenol 
• 120-80-9 benzene-1,2-diol 
• 33371-97-0 2-ethoxycyclohexanone 
• 103-73-1 Phenetole 
• 36315-01-2 4,6-dimethoxy-2-aminopyrimidine 

Downstream Products

• 99448-04-1 (2-Ethoxy-phenoxy)-trimethyl-silane 
• 78880-50-9 (2R,3R,4S,5R,6S)-3,4,5-Tris-benzyloxy-2-benzyloxymethyl-6-(2-ethoxy-phenoxy)-tetrahydro-pyran 
• 78880-50-9 (2R,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-2-benzyloxymethyl-6-(2-ethoxy-phenoxy)-tetrahydro-pyran 
• 79306-77-7 3-dimethylamino-2-phenylpropyl acetate 
• 79306-63-1 N,N-dimethyl-3-(2-ethoxyphenoxy)-2-phenylpropylamine 
• 133534-59-5 (RS,SR) 2-hydroxy-3-(2-ethoxyphenoxy)-3-benzenepropanoic acid 
• 133534-59-5 (RS,RS) 2-hydroxy-3-(2-ethoxyphenoxy)-3-benzenepropanoic acid 
• 92208-20-3 1-[3-(2-Ethoxy-phenoxy)-3-phenyl-propyl]-4-methyl-piperazine 
• 92208-21-4 1-Benzyl-4-[3-(2-ethoxy-phenoxy)-3-phenyl-propyl]-piperazine 
• 98819-70-6 (+)-(2R,3S)-3-(2-ethoxyphenoxy)-1,2-dihydro-3-phenylpropane 
• 74321-30-5 (3-Ethoxy-4-hydroxyphenyl)acetaldehyd-dimethylhydrazon 
• 78718-30-6 2'-Ethoxyphenyl trans-4-guanidinomethylcyclohexanecarboxylate hydrochloride 
• 104778-55-4 1-benzyl-3-<(2-ethoxyphenoxy)methyl>-3-piperidinol 
• 104778-59-8 1-benzyl-3-<(2-ethoxyphenoxy)methyl>piperidine 

Relevant articles and documents

Phase transfer catalyzed synthesis of o-ethoxyphenol under microwave irradiation

o-Chlorophenol reacted with ethanol in the presence of sodium hydroxide and phase transfer catalyst under microwave irradiation and gave o-ethoxyphenol conveniently within a few minutes, and the isolated yield of o-ethoxyphenol vary from 69% to 82%.

Thermodynamic analysis of liquid-phase dehydrogenation of o-ethoxycyclohexanol to guaethol

The standard molar enthalpies of formation, standard molar entropies and molar heat capacities of o-ethoxycyclohexanol and guaethol in liquid phase are calculated based on the Benson group contribution method. The function formulas of reaction enthalpy ch

Highly selective conversion of guaiacol to: Tert -butylphenols in supercritical ethanol over a H2WO4 catalyst

The conversion of guaiacol is examined at 300 °C in supercritical ethanol over a H2WO4 catalyst. Guaiacol is consumed completely, meanwhile, 16.7% aromatic ethers and 80.0% alkylphenols are obtained. Interestingly, tert-butylphenols are produced mainly with a high selectivity of 71.8%, and the overall selectivity of 2,6-di-tert-butylphenol and 2,6-di-tert-butyl-4-ethylphenol is as high as 63.7%. The experimental results indicate that catechol and 2-ethoxyphenol are the intermediates. Meanwhile, the WO3 sites play an important role in the conversion of guaiacol and the Br?nsted acid sites on H2WO4 enhance the conversion and favour a high selectivity of the tert-butylphenols. The recycling tests show that the carbon deposition on the catalyst surface, the dehydration and partial reduction of the catalyst itself are responsible for the decay of the H2WO4 catalyst. Finally, the possible reaction pathways proposed involve the transetherification process and the alkylation process during guaiacol conversion.