94-71-3

Usage

Chemical Properties

clear colorless to yellow liquid

Uses

Different sources of media describe the Uses of 94-71-3 differently. You can refer to the following data:
1. 2-Ethoxyphenol is used in the studies on the inhibition of oral bacteria by phenolic compounds. Studies on the prostagladins cyclooxygenase inhibition by phenolic compounds. Reagent for the stereoselective preparation of (arylthiomethyl)morpholines as selective norepinephrine reuptake inhibitors and dual serotonin/norepinephrine reuptake inhibitors.
2. 2-Ethoxyphenol has been used as carbon and energy supplement in the growth medium of red-pigmented coryneform bacterium, Rhodococcus rhodochrous strain 116.

General Description

2-Ethoxyphenol is a smoke flavour compound and forms complexes with iron (III).

InChI:InChI=1/C8H10O2/c1-2-10-8-6-4-3-5-7(8)9/h3-6,9H,2H2,1H3

Upstream product

• 10467-10-4 ethylmagnesium iodide 
• 95-47-6 o-xylene 
• 860556-23-6 1-ethoxy-2-benzyloxy-benzene 
• 2050-46-6 1,2-diethoxybenzene 
• 17600-72-5 2-ethoxyanisole 
• 56-23-5 tetrachloromethane 
• 917-64-6 methyl magnesium iodide 
• 60-29-7 diethyl ether 
• 75-00-3 chloroethane 
• 34789-97-4 pyrocatechol monosodium salt 
• 74-96-4 ethyl bromide 
• 120-80-9 benzene-1,2-diol 
• 64-67-5 diethyl sulfate 
• 75-03-6 ethyl iodide 

Downstream Products

• 85068-49-1 carbonic acid bis-(2-ethoxy-phenyl ester) 
• 78268-44-7 2-ethoxyphenyl acetate 
• 2050-46-6 1,2-diethoxybenzene 
• 6781-16-4 (2-ethoxyphenoxy)methyl cyanide 
• 66644-03-9 1-(3-ethoxy-4-hydroxy-phenyl)-2,2,2-trichloro-ethanol 
• 1666-74-6 1-allyloxy-2-ethoxybenzene 
• 3250-73-5 2-(2-ethoxyphenoxy)ethanol 
• 3698-67-7 O-<α,α'-Dichlorisopropyl>-O-<2-aethoxyphenyl>-schwefligsaeureester 
• 59748-10-6 4-Chloro-1-(2-ethoxyphenoxy)-2-butanol 
• 53326-07-1 4-[(Dichloro-fluoro-methylsulfanyl)-trifluoromethyl-amino]-benzoic acid 2-ethoxy-phenyl ester 
• 53325-75-0 3-[(Dichloro-fluoro-methylsulfanyl)-trifluoromethyl-amino]-benzoic acid 2-ethoxy-phenyl ester 
• 52730-46-8 (S)-2-(2-ethoxy-phenoxymethyl)-morpholine 
• 52145-60-5 4-(4-Chloro-phenylsulfanyl)-2-ethoxy-phenol 
• 99448-04-1 (2-Ethoxy-phenoxy)-trimethyl-silane 

Relevant academic research and scientific papers

Phase transfer catalyzed synthesis of o-ethoxyphenol under microwave irradiation

o-Chlorophenol reacted with ethanol in the presence of sodium hydroxide and phase transfer catalyst under microwave irradiation and gave o-ethoxyphenol conveniently within a few minutes, and the isolated yield of o-ethoxyphenol vary from 69% to 82%.

Thermodynamic analysis of liquid-phase dehydrogenation of o-ethoxycyclohexanol to guaethol

The standard molar enthalpies of formation, standard molar entropies and molar heat capacities of o-ethoxycyclohexanol and guaethol in liquid phase are calculated based on the Benson group contribution method. The function formulas of reaction enthalpy ch

Hollow, mesoporous, eutectic Zn1?xMgxO nano-spheres as solid acid-base catalysts for the highly regio-selectiveO-methylation of 1,2-diphenols

The highly regio-selectiveO-methylation of catechol with dimethyl carbonate (DMC), catalyzed by a solid acid-base catalyst, is an environmentally friendly chemical process for industrial production of guaiacol. However, a guaiacol yield below 84% and high reaction temperature above 280 °C limit its industrial application. Here, hollow, mesoporous Zn1?xMgxO nano-spheres with a eutectic structure, denoted as Zn1?xMgxO HMNSs (x= 0.012-0.089), are facilely fabricatedviathe calcination of Mg2+/Zn2+ion-adsorbing carbon spheres at 500 °C in air. In theO-methylation of catechol with DMC at 180 °C, Zn1?xMgxO HMNSs (x= 0.052) afford guaiacol in 95.5% yield with a complete catechol conversion. Furthermore, 89.0-95.3% mono-ether yields with high 1,2-diphenol conversions (94.5-100%) are also obtained for the other 1,2-diphenols bearing -CH3and -Br groups. Moreover, a plausible mechanism for highly selectiveO-methylation of catechol with DMC is proposed, in which the single-site activation and double-site activation of phenolic hydroxyls by the basic oxygen of Mg-O afford guaiacol and veratrole, respectively.

Method for simultaneously preparing 2-ethoxyphenol and 1,3-benzodioxolane-2-one

The invention belongs to the field of organic synthesis, and provides a method for simultaneously preparing 2-ethoxyphenol and 1,3-benzodioxolane-2-one. According to the preparation method, catechol and diethyl carbonate are subjected to transesterification under the action of a catalyst, so that the 2-ethoxyphenol and the 1,3-benzodioxolane-2-one can be obtained. The combined selectivity of the 2-ethoxyphenol and the 1,3-benzodioxolane-2-one can reach 97%, and the method has the advantages of high conversion rate, high selectivity, high economic benefit, environmental friendliness and the like.

Highly selective conversion of guaiacol to: Tert -butylphenols in supercritical ethanol over a H2WO4 catalyst

The conversion of guaiacol is examined at 300 °C in supercritical ethanol over a H2WO4 catalyst. Guaiacol is consumed completely, meanwhile, 16.7% aromatic ethers and 80.0% alkylphenols are obtained. Interestingly, tert-butylphenols are produced mainly with a high selectivity of 71.8%, and the overall selectivity of 2,6-di-tert-butylphenol and 2,6-di-tert-butyl-4-ethylphenol is as high as 63.7%. The experimental results indicate that catechol and 2-ethoxyphenol are the intermediates. Meanwhile, the WO3 sites play an important role in the conversion of guaiacol and the Br?nsted acid sites on H2WO4 enhance the conversion and favour a high selectivity of the tert-butylphenols. The recycling tests show that the carbon deposition on the catalyst surface, the dehydration and partial reduction of the catalyst itself are responsible for the decay of the H2WO4 catalyst. Finally, the possible reaction pathways proposed involve the transetherification process and the alkylation process during guaiacol conversion.

A utilizes ethylene directly producing O-ethoxyl phenol method (by machine translation)

The invention relates to a use of ethylene in the direct production of O-ethoxyl phenol method, comprises the following steps: to join the catechol in the autoclave, the solvent, the main catalyst and the auxiliary catalyst, sealing the high-pressure autoclave, for most of the air in the pump coke, opening stirring and heating to 180 - 260 °C; the ethylene gas to make the kettle pressure reaches the 0.6 - 1.6 mpa, maintained at the pressure under the reaction 4 - 8 hours, after the reaction is completed through the pressure relief valve is not involved in the reaction of the released ethylene gas, lowering the temperature to 100 °C following, pressure-reducing filter and recycle catalyst; the reaction solution through the column chromatography recovery catechol and obtaining a product, or by reduced pressure distillation to remove the majority of the solvent to obtain catechol and product-based crude product, the crude product rectification to get the pure product O-ethoxy group phenol; the process of the invention is simple, short reaction route, the production efficiency is high, can reduce the production cost, and can reduce the generation of three wastes with the treatment cost, very environmental protection. (by machine translation)

METHOD FOR PREPARING P-HYDROXYMANDELIC COMPOUNDS IN STIRRED REACTORS

The process allows the preparation of a p-hydroxymandelic compound, comprising at least one step of condensation of at least one aromatic compound bearing at least one hydroxyl group and whose para position is free, with glyoxylic acid, the condensation reaction being performed in at least one reactor equipped with at least one mixing means, the specific mixing power being between 0.1 kW/m3 and 15 kW/m3. In addition, the invention also relates to a process for preparing a 4-hydroxyaromatic aldehyde by oxidation of this p-hydroxymandelic compound.

Direct oxidation of the C(sp2)-C(sp3) bond from benzyltrimethylsilanes to phenols

A novel pathway for direct conversion of benzylsilanes to phenols by oxidation with Na2S2O8 and oxygen is efficiently developed under mild and neutral conditions. The reaction shows good functional group tolerance to afford phenols in moderate yields. The possible mechanism is proposed based on the isotopic labeling trials.

Preparation method for converting ortho-position ethyl vanillin into ethoxyphenol

The invention belongs to the field of organic synthesis and particularly relates to a preparation method for converting ortho-position ethyl vanillin into ethoxyphenol. The method comprises the following steps: 1, adding an appropriate amount of ortho-position ethyl vanillin into a reaction kettle, and heating the ortho-position ethyl vanillin so that the ortho-position ethyl vanillin can be molten to be in the liquid state; 2, starting stirring, and adding a composite catalyst into the reaction kettle; 3, conducting heating and raising the temperature to 120-160 DEG C, conducting a reaction, and conducting a backflow reaction for 1-5 hours; 4, conducting press filtering, and recycling the composite catalyst; 5, conducting simple distillation on filtrate, so that a product, namely ethoxyphenol, is obtained, wherein the mass ratio of the ortho-position ethyl vanillin to the ethoxyphenol is 1: (0.01-0.07). By means of the preparation method, the problem that at present, ortho-position ethyl vanillin cannot be disposed is solved, an ethyl vanillin manufacturer can synthesize ortho-position ethyl vanillin into ethoxyphenol independently by means of the method, accumulation of ortho-position ethyl vanillin is reduced, it is beneficial to cycle use of chemical raw materials, and environmental pollution is reduced.

In the cleaving org. compd. ether bond

PROBLEM TO BE SOLVED: To provide a cleavage method of a methyl ether bond in an organic compound for cleaving the methyl ether bond in the organic compound which is usable as various synthesis methods for organic compounds without especially using a solvent or a post-treatment agent. SOLUTION: The method is characterized in that an organic compound having a methyl ether bond is contacted with hydrogen iodide gas at room temperature without dissolving a solvent so that the methyl ether bond is cleaved. COPYRIGHT: (C)2013,JPOandINPIT