121050-12-2Relevant articles and documents
Azetidine derivatives to treat memory and learning disorders
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, (2008/06/13)
This invention relates to novel azetidines and derivatives thereof, as well as to pharmaceutical compositions and methods of treating memory and learning disorders. Another aspect of the invention relates to a method of utilizing the compounds and composi
Azetidine derivatives, compositions and methods of treating
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, (2008/06/13)
This invention relates to novel azetidines and derivative thereof, as well as to pharmaceutical compositions and methods of treating memory and learning disorders. Another aspect of the invention relates to a method of utilizing the compounds and compositions as biological tools and materials for characterizing excitatory amino acid receptor systems. A further aspect of the invention relates to a method of treating PCP toxicity and abuse.
Synthesis and Bioactivity of a New Class of Rigid Glutamate Analogues. Modulators of the N-Methyl-D-aspartate Receptor
Kozikowski, Alan P.,Tueckmantel, Werner,Reynolds, Ian J.,Wroblewski, Jarda T.
, p. 1561 - 1571 (2007/10/02)
A variety of derivatives of azetidine-2,4-dicarboxylic acid were synthesized and examined for their ability to stimulate 45Ca2+ uptake in cultures of cerebellar granule cells.Of the compounds tested, the cis-azetidine-2,4-dicarboxylic acid (10f