121105-78-0

Basic information

• Product Name: 1-CHLORO-3-METHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBONITRILE
• Synonyms: Pyrido[1,2-a]benziMidazole-4-carbonitrile,1-chloro-3-Methyl-
• CAS NO: 121105-78-0
• Molecular Formula: C₁₃H₈ClN₃
• Molecular Weight: 241.68
• Mol File: 121105-78-0.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.36g/cm³
• Refractive Index: 1.696
• CAS DataBase Reference: 1-CHLORO-3-METHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-3-METHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBONITRILE(121105-78-0)
• EPA Substance Registry System: 1-CHLORO-3-METHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBONITRILE(121105-78-0)

Safety Data

• Hazardous Substances Data: 121105-78-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-CHLORO-3-METHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBONITRILE is used as a building block in organic synthesis for the preparation of various chemical compounds. Its unique structure allows for the formation of new chemical entities through reactions such as addition, substitution, and condensation.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-CHLORO-3-METHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBONITRILE is used as an intermediate in the synthesis of pharmaceuticals. Its presence in the molecular structure can contribute to the development of new drugs with potential therapeutic applications.
Used in Pharmaceutical Industry:
1-CHLORO-3-METHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBONITRILE is used as a key component in the development of new pharmaceuticals. Its incorporation into drug molecules can lead to the discovery of novel therapeutic agents with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical industry, 1-CHLORO-3-METHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBONITRILE is used as a precursor in the synthesis of agrochemicals. Its potential biological activities make it a valuable compound for the development of new pesticides, herbicides, and other agricultural chemicals.
Used in Biological Activity Studies:
1-CHLORO-3-METHYL-BENZO[4,5]IMIDAZO[1,2-A]PYRIDINE-4-CARBONITRILE is used as a subject of biological activity studies to investigate its potential pharmacological properties. Research in this area can lead to the identification of new drug targets and the development of innovative therapeutic agents.

InChI:InChI=1/C13H8ClN3/c1-8-6-12(14)17-11-5-3-2-4-10(11)16-13(17)9(8)7-15/h2-6H,1H3

Upstream product

• 60792-57-6 3-methyl-1-oxo-1H,5H-pyrido<1,2-a>benzimidazole-4-carbonitrile 
• 4414-88-4 1H-benzimidazol-2-acetonitrile 

Downstream Products

• 121105-81-5 3-methyl-1-(triphenylphosphoranylideneamino)pyrido<1,2-a>benzimidazole-4-carbonitrile 

Relevant articles and documents

Novel pyridobenzimidazole derivatives exhibiting antifungal activity by the inhibition of β-1,6-glucan synthesis

Based on the HTS hit compound 1a, an inhibitor of β-1,6-glucan synthesis, we synthesized novel pyridobenzimidazole derivatives and evaluated their antifungal activity. Among the compounds synthesized, we identified the potent compound 15e, which exhibits

IMIDAZO(1,2-a)PYRIDINE DERIVATIVE

A compound reprsented by the following formula (I), its salts or nsolvates thereof capable of specifically or selectively expressig an antifungal activity in a broad spectrum based on the novel mechanism thereof of 1,6-β-glucan synthesis inhibition, and an antifungal agent containing any of them.

Benzimidazole condensed ring systems. 2 [1]. New synthesis of substituted 1-oxo-1H,5-H-pyrido[1,2-a]benzimidazole-4-carbonitriles and related derivatives

The synthesis of some 3-substituted and 2,3-disubstituted-1-oxo-1H,5-H-pyrido[1,2-a]benzimidazole-4-carbonitr les 5,6 by fusing 1H-benzimidazole-2-acetonitrile 1 with some β-keto esters 2,4 in the presence of ammonium acetate or with ethyl β-aminocrotonat