1211284-11-5

Basic information

• Product Name: 3-Phenyloxetan-3-amine hydrochloride, (3-Aminooxetan-3-yl)benzene hydrochloride
• Synonyms: 3-Amino-3-phenyloxetane hydrochloride;3-Phenyloxetan-3-amine hydrochloride, (3-Aminooxetan-3-yl)benzene hydrochloride;3-Phenyl-3-oxetanaMine hydrochloride;3-phenyloxetan-3-aMine hydrochloride;3-phenyl-3-Oxetanamine hydrochloride (1:1)
• CAS NO: 1211284-11-5
• Molecular Formula: C₉H₁₁NO*ClH
• Molecular Weight: 185.65068
• Mol File: 1211284-11-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-Phenyloxetan-3-amine hydrochloride, (3-Aminooxetan-3-yl)benzene hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenyloxetan-3-amine hydrochloride, (3-Aminooxetan-3-yl)benzene hydrochloride(1211284-11-5)
• EPA Substance Registry System: 3-Phenyloxetan-3-amine hydrochloride, (3-Aminooxetan-3-yl)benzene hydrochloride(1211284-11-5)

Safety Data

• Hazardous Substances Data: 1211284-11-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-Phenyloxetan-3-amine hydrochloride, (3-Aminooxetan-3-yl)benzene hydrochloride is used as a building block in organic synthesis for the creation of various biologically active compounds. Its unique structure and reactivity allow for the development of new molecules with potential applications in various fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-Phenyloxetan-3-amine hydrochloride, (3-Aminooxetan-3-yl)benzene hydrochloride is utilized as a key intermediate in the synthesis of drug candidates. Its properties make it suitable for the development of new medications with improved efficacy and reduced side effects.
Used in Medicinal Chemistry:
3-Phenyloxetan-3-amine hydrochloride, (3-Aminooxetan-3-yl)benzene hydrochloride is employed in medicinal chemistry for the design and optimization of novel therapeutic agents. Its unique structural features and reactivity contribute to the discovery of new compounds with potential therapeutic benefits.
Used in Drug Development:
In the field of drug development, 3-Phenyloxetan-3-amine hydrochloride, (3-Aminooxetan-3-yl)benzene hydrochloride serves as a valuable component in the formulation of new drugs. Its stability as a hydrochloride salt and its compatibility with various chemical reactions make it an ideal candidate for the development of innovative pharmaceutical products.

Upstream product

• 1211283-99-6 2-methyl-N-(3-phenyloxetan-3-yl)propane-2-sulfinamide 

Downstream Products

• 1380656-45-0 4-fluoro-2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(3-phenyloxetan-3-ylcarbamoyl)phenyl)benzofuran-3-carboxamide 

Relevant articles and documents

Discovery of N-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors

NLRP3 inflammasome mediated release of interleukin-1β (IL-1β) has been implicated in various diseases. In this study, rationally designed mimics of sulfonylurea moiety were investigated as NLRP3 inhibitors. Our results culminated into discovery of series of unprecedented N-cyano sulfoximineurea derivatives as potent NLRP3 inflammasome inhibitors. Compound 15 (IC50 = 7 nM) and analogues were found to be highly potent and selective NLRP3 inflammasome inhibitor with good pharmacokinetic profile. These effects translate in vivo, as 15, 29, and 34 significantly inhibit NLRP3 dependent IL-1β secretion in mice.

BENZOFURANE DERIVATIVES FOR THE TREATMENT OF HEPATITITS C

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and maybe useful in treating those infected with HCV.

Reactions of oxetan-3-tert-butylsulfinimine for the preparation of substituted 3-aminooxetanes

(Figure Presented) The oxetane ring Is useful In drug discovery as a bioisostere for both the geminal dimethyl group and the carbonyl group. A convenient, straightforward approach to access structurally diverse 3-aminooxetanes through the reactivity of oxetan-3-tert-butylsulfinimine and the corresponding sulfinylaziridine Is described.