Efficient synthesis and X-ray structures of new α-quinolin-3-yl- α-aminonitriles and derivatives
This study describes the synthesis of novel α-aminonitrile derivatives possessing a quinoline subunit via a Strecker reaction. Chiral α-methylbenzylamines were used to carry out the diastereoselective version of this sequence. Conversion of an enantiopure 2-chloroquinolin-3-yl derivative into the corresponding α-aminoester resulted in the concomitant formation of a 2(1H)-quinolinone moiety and a partial racemization. Single crystal X-ray structures are reported for three compounds.
Ladraa, Souheila,Berrée, Fabienne,Bouraiou, Abdelmalek,Bouacida, Sofiane,Roisnel, Thierry,Carboni, Bertrand,Belfaitah, Ali
p. 749 - 752
(2013/02/25)
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