73568-25-9Relevant articles and documents
C-(2-chloroquinoline-3-yl)-N-phenyl nitrone: New synthetic antioxidant inhibits proliferation and induces apoptosis of breast carcinoma MCF-7 cells
Ramadan, Mohamed,Gamal-Eldeen, Amira M.,Abdel-Aziz, Mohamed,Abuo-Rahma, Gamal El-Din,Abdel-Nabi, Hisham,Nagib, Abdel-Hamid
, p. 242 - 249 (2006)
In this work, a new quinoline nitrone derivative, C-(2-chloroquinoline-3- yl)-N-phenyl nitrone (CQPN) was successfully prepared and proved by spectral analysis. The antioxidant activity of CQPN against various radicals was investigated and its anti-cancer
Synthesis of some complex pyrano[2,3-b]- and pyrido[2,3-b]quinolines from simple acetanilides via intramolecular domino hetero Diels-Alder reactions of 1-oxa-1,3-butadienes in aqueous medium
Baruah, Biswajita,Bhuyan, Pulak J.
, p. 7099 - 7104 (2009)
Some complex pyrano[2,3-b]- and pyrido[2,3-b]quinolines were synthesized from simple acetanilides via intramolecular domino hetero Diels-Alder reactions of 1-oxa-1,3-butadienes using water as solvent.
A novel fluorescent chemosensor for Zn(II) based on 1,2-(2′-oxoquinoline-3′-yl-methylideneimino)ethane
Liu, Zeng-chen,Wang, Bao-dui,Yang, Zheng-yin,Li, Tian-rong,Li, Yong
, p. 606 - 608 (2010)
A new bis Schiff-base ligand (1,2-(2′-oxoquinoline-3′-yl-methylideneimino)ethane, QSB) derived from 2-oxo-quinoline-3-carbaldehyde and ethylene diamine was synthesized and characterized by 1H-NMR. Spectroscopic investigation revealed that the compound exhibited a high selectivity toward Zn(II) ion over other metal ions in acetonitrile solution. In addition, the crystal structure showed that the coordination form of QSB and Zn(II) was 1:1.
Indium chloride/silica gel supported synthesis of pyrano/thiopyranoquinolines through intramolecular imino Diels-Alder reaction using microwave irradiation
Ramesh, Ekambaram,Sree Vidhya, Tarakkad Krishnaji,Raghunathan, Raghavachary
, p. 2810 - 2814 (2008)
A facile synthesis of pyrano/thiopyranoquinolines is accomplished in excellent yields through imino Diels-Alder reaction using silica gel impregnated with indium trichloride as catalyst.
Efficient synthesis of quinolo-oxepanes through [3+2] cycloaddition reaction of α,β-unsaturated ester with unstabilized azomethine ylides
Saravanan, Nagarajan,Arthanareeswari, Maruthapillai,Kamaraj, Palanisamy,Sivakumar, Bitragunta
, p. 3667 - 3670 (2015)
New functionalized quinolo-oxepane were achieved by intramolecular 1,3-dipolar cycloaddition reaction of α,β-unsaturated ester with unstabilized azomethine ylides derived from various α-amino acids with high stereo selectivity and good yields. These deriv
One-pot three-component synthesis of 2H-thiopyrano[2,3-b]quinoline-2,3-dicarboxylates from 2-mercaptoquinoline-3-carbaldehydes, dialkyl acetylenedicarboxylates and Ph3P
Alizadeh, Abdolali,Roosta, Atefeh,Amir Ashjaee Asalemi, Kaveh
, p. 435 - 442 (2018)
An extremely concise one-pot procedure toward the synthesis of 2H-Thiopyrano [2,3-b]quinoline-2,3-dicarboxylates whose applications as medicines is predictable has been established. This approach produces three fused rings evolving from the formation of four new carbon–carbon bonds and a stereogenic center in a one-pot protocol.
Visible light induced nano copper catalyzed one pot synthesis of novel quinoline bejeweled thiobarbiturates as potential hypoglycemic agents
Angajala, Gangadhara,Aruna, Valmiki,Subashini, Radhakrishnan
, p. 1446 - 1460 (2021)
An efficient visible light induced one pot three component approach for the synthesis of new quinoline bejeweled thiobarbiturates via Knoevenagel condensation and N-alkylation using copper nanoparticles (CuNPs) have been reported. These copper nanoparticles due to their diverse properties, smaller size (50–100 nm), and high surface area to volume ratio exhibit promising features for the reaction response such as the shorter reaction time, simple work-up procedure, clean reaction profiles, and excellent product yields through reusability of the catalyst upto five cycles. The recovered catalyst was successfully characterized by EDAX and AFM analysis. In silico molecular docking studies were carried out to find out the effective binding affinity of the synthesized quinoline derivatives toward PPARγ protein. The results obtained showed that compounds 4d, 4e, and 4f possess good binding interaction toward PPARγ with binding energy of ?7.4, ?7.2 and, ?7.6 k.cal/mol which was greater than standard rosiglitazone (?6.4 k.cal/mol) and comparable to that of standard pioglitazone (?7.9 k.cal/mol). In vitro α-amylase and α-glucosidase assays were performed for hypoglycemic activity evaluation. The compounds 4e and 4f at a concentration of 100 μg/ml showed 82.13% and 83.26% inhibition toward α-glucosidase, 78.30% and 84.18% inhibition toward α-amylase which was higher than standard pioglitazone and on par to that of rosiglitazone and acarbose.
α-cyclisation of tertiary amines: Synthesis of some novel annelated quinolines via a three-component reaction under solvent-free conditions
Devi, Ipsita,Baruah, Biswajita,Bhuyan, Pulak J.
, p. 2593 - 2596 (2006)
Synthesis of some novel classes of quinolizine-, indolizine- and pyrido-1,4-oxazine-fused quinoline derivatives via a three-component reaction under solvent-free conditions by exploring the 'tertiary amine effect' reaction strategy. Georg Thieme Verlag Stuttgart.
Hydrolysis of phosphoryl trichloride (POCl3): Characterization, in situ detection, and safe quenching of energetic metastable intermediates
Achmatowicz, Micha M.,Thiel, Oliver R.,Colyer, John T.,Tomaskevitch, Joe,Tedrow, Jason S.,Larsen, Robert D.,Hu, Jack,Elipe, Maria Victoria Silva
, p. 1490 - 1500 (2010)
The accumulation of metastable intermediates resulting from the incomplete hydrolysis of phosphoryl trichloride-containing mixtures carries the risk of latent exothermic events. Significant accumulation of two P-Cl species containing reactive phosphorus-c
Crystal structures, DNA-binding and cytotoxic activities studies of Cu(II) complexes with 2-oxo-quinoline-3-carbaldehyde Schiff-bases
Liu, Zeng-Chen,Wang, Bao-Dui,Li, Bo,Wang, Qin,Yang, Zheng-Yin,Li, Tian-Rong,Li, Yong
, p. 5353 - 5361 (2010)
Three novel 2-oxo-quinoline-3-carbaldehyde Schiff-bases and their Cu(II) complexes were synthesized. The molecular structures of Cu(II) complexes were determined by X-ray crystal diffraction. The DNA-binding modes of the complexes were also investigated b
