A method for preparing a deuterium generation of advantage holds that Wei
The invention discloses a preparation method of deuterium-labeled Ritonavir. According to the method, isobutyric acid-D6 is used as a starting raw material, and deuterium-labeled Ritonavir is synthesized through seven reactions. Optimal preparation steps and reaction conditions are screened through a lot of experiments, the whole process is reasonable in design and strong in operability; the purity of deuterium-labeled Ritonavir prepared by the preparation method provided by the invention is greater than 98 percent; the yield of the deuterium-labeled Ritonavir can be greater than 80 percent; and the isotope abundance is greater than 99 percent. The deuterium-labeled Ritonavir prepared by the preparation method provided by the invention can provide a test sample for research on metabolic mechanism of Ritonavir and has an important application value.
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(2018/02/04)
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