1217849-53-0

Basic information

• Product Name: D-2,4-DINITROPHE
• Synonyms: D-2,4-DINITROPHE;D-2,4-DINITROPHENYLALANINE
• CAS NO: 1217849-53-0
• Molecular Formula: C9H9N3O6
• Molecular Weight: 255.18
• Product Categories: Phenylalanine analogs and other aromatic alpha amino acids
• Mol File: 1217849-53-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D-2,4-DINITROPHE(CAS DataBase Reference)
• NIST Chemistry Reference: D-2,4-DINITROPHE(1217849-53-0)
• EPA Substance Registry System: D-2,4-DINITROPHE(1217849-53-0)

Safety Data

• Hazardous Substances Data: 1217849-53-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Production:
D-2,4-Dinitrophenol is used as a key component in the production of various dyes, wood preservatives, and explosives due to its chemical properties and reactivity.
Used in Weight Loss Supplements (with caution):
D-2,4-Dinitrophenol is used as a weight loss supplement for its ability to increase the body's metabolic rate and energy expenditure. However, due to its high toxicity and potential for severe side effects, its use in this application is strongly discouraged and regulated in many countries.
Used in Research and Development:
D-2,4-Dinitrophenol is utilized in scientific research and development for studying its effects on metabolism and energy expenditure, as well as exploring potential applications in various industries.

Upstream product

• 949-99-5 4-nitro-3-phenyl-L-alanine 
• 63-91-2 L-phenylalanine 

Relevant articles and documents

Solubilities of 2,4-Dinitro-L-phenylalanine in Monosolvents at (273.15 to 368.15) K

The solubilities of amino acid, 2,4-dinitro-l-phenylalanine in monosolvents water, methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetone, ethyl acetate, and 1,2-dichloroethane were measured from (273.15 to 368.15) K at atmospheric pressure using the synthetic method. The solubility was determined by a laser monitoring observation technique. The experimental solubilities were regressed by the modified Apelblat equation with the relative deviation less than 2.5 %.

Transformation of l-phenylalanine to (S)-indoline-2-carboxylic acid without group-protection

(S)-Indoline-2-carboxylic acid was synthesized by use of a nitro amination approach with l-phenylalanine as chiral pool. The first step of the synthesis was nitration of l-phenylalanine, with urea nitrate (UN)/H2SO 4 as nitrating reagent, to give 2,4-dinitro-l-phenylalanine in 75.7 % yield in one-pot synthesis and 69.1 % yield by step-wise nitration. Intramolecular nitro amination of 2,4-dinitro-l-phenylalanine gave (S)-6-nitro-indoline-2-carboxylic acid in 65.7 % yield and more than 99.5 % enantiomeric excess (ee). The title compound, (S)-indoline-2-carboxylic acid, was obtained in 85.9 % yield and high ee by one-pot transformation of (S)-6-nitroindoline-2-carboxylic acid. The total synthesis consisted of three operations and gave the title compound in 42 % yield and more than 99.5 % ee.