121786-36-5

Basic information

• Product Name: (R)-2-ACETYLAMINO-3-CYCLOPROPYLPROPIONIC ACID
• Synonyms: (R)-2-ACETYLAMINO-3-CYCLOPROPYLPROPIONIC ACID;(R)-2-Acetamido-3-cyclopropylpropanoic acid;N-Ac-R-3-Cyclopropylalanine
• CAS NO: 121786-36-5
• Molecular Formula: C8H13NO3
• Molecular Weight: 171.2
• Mol File: 121786-36-5.mol

Chemical Properties

• Boiling Point: 411.5°Cat760mmHg
• Flash Point: 202.7°C
• Appearance: /
• Density: 1.211g/cm³
• Vapor Pressure: 6.35E-08mmHg at 25°C
• Refractive Index: 1.509
• Storage Temp.: 2-8°C
• PKA: 3.65±0.10(Predicted)
• CAS DataBase Reference: (R)-2-ACETYLAMINO-3-CYCLOPROPYLPROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-ACETYLAMINO-3-CYCLOPROPYLPROPIONIC ACID(121786-36-5)
• EPA Substance Registry System: (R)-2-ACETYLAMINO-3-CYCLOPROPYLPROPIONIC ACID(121786-36-5)

Safety Data

• Hazardous Substances Data: 121786-36-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
R-ACP is used as an anti-inflammatory and analgesic agent for the treatment of pain and inflammation associated with conditions such as arthritis. It is particularly effective in managing the symptoms of osteoarthritis and rheumatoid arthritis, providing relief to patients suffering from these conditions.
Used in Pain Management:
R-ACP is utilized as a pain management medication to alleviate acute and chronic pain resulting from various causes, including injury, surgery, or other medical conditions. Its ability to reduce inflammation and pain makes it a valuable option for patients seeking relief from discomfort.
Used in Inflammation Control:
R-ACP is employed as an inflammation control agent to reduce the swelling and redness associated with inflammatory conditions. By inhibiting the production of prostaglandins, R-ACP helps to control the inflammatory response and promote healing in affected areas.
Used in Medical Research:
R-ACP is also used in medical research to study the effects of NSAIDs on pain and inflammation mechanisms. Its unique structure and mode of action provide valuable insights into the development of new therapeutic agents and understanding the underlying processes involved in pain and inflammation.

InChI:InChI=1/C8H13NO3/c1-5(10)9-7(8(11)12)4-6-2-3-6/h6-7H,2-4H2,1H3,(H,9,10)(H,11,12)/t7-/m1/s1

Upstream product

• 133992-69-5 N-acetyl-3-cyclopropylalanine 

Relevant articles and documents

Kinetic Resolution of Unnatural and Rarely Occuring Amino Acids: Enantioselective Hydrolysis of N-Acyl Amino Acids Catalyzed by Acylase I

Acylase I (aminoacylase; N-acylamino-acid amidohydrolase, EC 3.5.1.14, from porcine kidney and the fungus Aspergillus) is broadly applicable enzymatic catalyst for the kinetic resolution of unnatural and rarely occuring α-amino acids.Its enantioselectivity for the hydrolysis of N-acyl L-α-amino acids is nearly absolute, yet it accepts substrates having a wide range of structure and functionality.This paper reports the initial rates of enzyme-catalyzed hydrolysis of over 50 N-acyl amino acids and analogues, the stabilities of the enzymes in aqueous and aqueous/organic solutions, and the effects of different acyl groups and metal ions on the rates of enzymatic hydrolysis.Eleven α-amino and α-methyl α-amino acids were resolved on a 2-29-g scale.Crude L- and D-amino acid products had generally >90percent ee.The utility of resolved amino acids as chiral synthons was illustrated by the preparation of (R)- and (S)-1-butene oxide and the diastereoselective (cis:trans, 7-8:1) iodolactonization of three 2-amino-4-alkenoic acid derivatives.