- SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME
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The present invention includes substituted arylmethyl ureas and heteroarylmethyl-ureas, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.
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Page/Page column 245; 246
(2020/07/07)
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- Organic small molecular fluorescent probe for detecting methanol and preparation method of organic small molecular fluorescent probe
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The invention discloses a preparation method of an organic small molecular fluorescent probe for detecting methanol. The preparation method comprises the following steps: firstly, preparing 1-(p-toluenesulfonyl) imidazole; secondly, preparing the organic small molecular fluorescent probe: adding a proper amount of 4-bromotriphenylamine and the 1-(p-toluenesulfonyl) imidazole into a tetrahydrofuran solution, and then adding a catalyst consisting of copper sulfate pentahydrate and sodium ascorbate into the solution; protecting by nitrogen and stirring for 12 hours, extracting with dichloromethane, drying by using anhydrous magnesium sulfate, and performing rotary evaporation to obtain a crude product; performing column chromatographic separation on the crude product by using ethyl acetate and petroleum ether, wherein the volume ratio of the ethyl acetate to the petroleum ether is 1 to (10 to 20), and separating to obtain a solid, namely the organic small molecular fluorescent probe for detecting the methanol. The fluorescent probe disclosed by the invention has a high fluorescent selective response to the methanol; the fluorescence intensity is remarkably enhanced along with the prolonging of time; the organic small molecular fluorescent probe has the advantages of easiness in preparation, good chemical stability, high sensitivity and the like.
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Paragraph 0017; 0019; 0020
(2017/10/14)
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- Rh-catalyzed transannulation of N-tosyl-1,2,3-triazoles with terminal alkynes
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The first transannulation of 1,2,3-triazoles with terminal alkynes into pyrroles is reported. The reaction proceeds in the presence of a Rh 2(oct)4/AgOCOCF3 binary catalyst system providing a straightforward approach to 1,2,4-trisubstituted pyrroles in good to excellent yields.
- Chattopadhyay, Buddhadeb,Gevorgyan, Vladimir
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supporting information; scheme or table
p. 3746 - 3749
(2011/09/13)
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- One-step conversion of azine N -oxides to α-1,2,4-triazolo-, 1,2,3-triazolo, imidazolo-, and pyrazoloheteroarenes
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Pyridine, quinoline, isoquinoline, azaindole, and pyrimidine N-oxides were converted to their α-triazole and α-diazole derivatives by treatment with the corresponding p-toluenesulfonylazoles and Hunigs base at elevated temperatures.
- Keith, John M.
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supporting information; experimental part
p. 2722 - 2725
(2010/07/17)
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- Pharmaceutical use of N-carbamoylazole derivatives
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The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a
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